| Serial measurement of serum basic fibroblast growth factor in patients with acute cerebral infarction. | |
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MedLine Citation:
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PMID: 16229951 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Basic fibroblast growth factor (bFGF) has been reported to be involved in the pathophysiological changes following cerebral infarction. Basic fibroblast growth factor is upregulated in the brain and conduces to neuroprotection and angiogenesis in experimental brain ischemia, but the change of serum bFGF in cerebral infarction patients has not been reported. In the present study, we investigated the dynamic changes of serum bFGF in 30 patients with acute cerebral infarction and found that serum bFGF increased significantly after cerebral infarction compared with the control group (p<0.05). Serum bFGF peaked on day 3 (15.46 +/- 5.58 pg/ml; p<0.01) and remained significantly elevated on day 14 following cerebral infarction. In this study, it was also found that the levels of bFGF with large infarction were higher at each time point than those with moderate or small infarction (p<0.05). There was a positive correlation between the peak level of bFGF and improvement of clinical neurological deficits scored by Scandinavian Stroke Scale (SSS) (r=0.596; p<0.05). These results suggest that the serum bFGF level increased significantly after cerebral infarction and the level of serum bFGF could be of value to estimate the infarction size and clinical prognosis. |
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Authors:
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Huailian Guo; Li Huang; Min Cheng; Xin Jin; Yafeng Zhao; Ming Yi |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2005-10-17 |
Journal Detail:
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Title: Neuroscience letters Volume: 393 ISSN: 0304-3940 ISO Abbreviation: Neurosci. Lett. Publication Date: 2006 Jan |
Date Detail:
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Created Date: 2005-12-06 Completed Date: 2006-02-09 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 56-9 Citation Subset: IM |
Affiliation:
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Department of Neurology, People's Hospital, Peking University, 11 Xi Zhi Men Nan Da Jie, Beijing 100044, China. guoh@bjmu.edu.cn |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adult Aged Aged, 80 and over Analysis of Variance Cerebral Infarction / blood* Enzyme-Linked Immunosorbent Assay / methods Female Fibroblast Growth Factor 2 / blood* Humans Male Middle Aged Severity of Illness Index Statistics as Topic Time Factors |
| Chemical | |
Reg. No./Substance:
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103107-01-3/Fibroblast Growth Factor 2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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