Document Detail

Serial magnetic resonance imaging in children with postinfectious encephalitis.
MedLine Citation:
PMID:  8980844     Owner:  NLM     Status:  MEDLINE    
We analyzed follow-up magnetic resonance images (MRI) in eight children with clinical postinfectious encephalitis (PIE), and discussed their pathogeneses. Three categories of MRI findings were apparent: (1) multifocal lesions in the white matter with/without basal ganglia involvement consistent with acute disseminated encephalomyelitis (ADEM) (three patients); (2) single or multifocal lesions localized only in the gray matter (two patients); and (3) localized lesions in the brain stem, basal ganglia or cerebellum. Some lesions in the patients in Categories 1 and 2 migrated or were resolved quickly, sometimes within 10 days. Gadolinium caused linear or spotty enhancement in the patients in Category 2. These findings suggest that Categories 1 and 2 are a self-limiting allergic angiopathy without demyelination. In contrast, the lesions in the patients in Category 3 were fixed, and not resolved within 6 months (three patients). The pathogenesis of Category 3 is not known. All except one patient had no prednisolone (PSL) therapy, however; all lesions were resolved completely or markedly reduced in size, which indicates PSL therapy is not always necessary in patients with PIE.
S Kimura; A Nezu; N Ohtsuki; T Kobayashi; H Osaka; S Uehara
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Brain & development     Volume:  18     ISSN:  0387-7604     ISO Abbreviation:  Brain Dev.     Publication Date:    1996 Nov-Dec
Date Detail:
Created Date:  1997-03-26     Completed Date:  1997-03-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7909235     Medline TA:  Brain Dev     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  461-5     Citation Subset:  IM    
Yokohama City University, Urafune Hospital, Department of Pediatrics, Kanagawa, Japan.
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MeSH Terms
Brain / radiography,  virology
Child, Preschool
Demyelinating Diseases / classification,  diagnosis,  virology
Encephalitis, Viral / classification,  diagnosis*,  physiopathology*
Follow-Up Studies
Gadolinium / diagnostic use
Magnetic Resonance Imaging*
Tomography, X-Ray Computed
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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