| Serial imaging of the brain. | |
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MedLine Citation:
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PMID: 15324857 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Epilepsy is a heterogeneous condition and it is likely that susceptibility factors and genetic predisposition interact with acquired influences such as seizures, AEDs, cerebral insults, subclinical seizures,and ongoing neurodegenerative processes to render certain individuals selectively vulnerable to cerebral damage. There is currently in substantial evidence to suggest that neuroprotective treatments that rely entirely on their anticonvulsant properties are sufficient to prevent the development of cerebral atrophy. The development of postprocessing techniques in serial imaging studies have allowed the detection of subtle changes, and it is likely that development of more sensitive imaging techniques with higher-strength MR magnets and novel MR contrasts will expand our understanding of the factors that render an individual susceptible to hippocampal and extratemporal atrophy. This will allow a more informed assessment of the role required of neuroprotective agents in arresting the progression of cerebral damage and dysfunction. |
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Authors:
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Rebecca S N Liu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Neuroimaging clinics of North America Volume: 14 ISSN: 1052-5149 ISO Abbreviation: Neuroimaging Clin. N. Am. Publication Date: 2004 Aug |
Date Detail:
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Created Date: 2004-08-24 Completed Date: 2005-03-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9211377 Medline TA: Neuroimaging Clin N Am Country: United States |
Other Details:
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Languages: eng Pagination: 437-48 Citation Subset: IM |
Affiliation:
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Department for Clinical and Experimental Epilepsy, Institute of Neurology, University College London, 33 Queen Square, London WC1N 3BG, UK. r.liu@ion.ucl.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Brain
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pathology* Brain Damage, Chronic / etiology Epilepsy / complications, pathology* Humans Magnetic Resonance Imaging / methods* Organ Size Sensitivity and Specificity |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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