Document Detail

Serial histologic investigation of squamous epithelial dysplasia associated with carcinoma of the esophagus.
MedLine Citation:
PMID:  1739906     Owner:  NLM     Status:  MEDLINE    
Esophageal dysplasia and carcinoma were reviewed in the surgical specimens obtained from 37 patients with squamous cell carcinoma and 4 with adenocarcinoma; special attention was paid to the continuity of both lesions. Two hundred forty dysplasias and 113 carcinomas in situ (CIS) were recognized in the squamous cell carcinoma cases and 2 dysplasias and no CIS in the adenocarcinoma cases. The CIS often was accompanied continuously by severe dysplasia rather than mild or moderate dysplasia, suggesting some relationship between the CIS and the severity of dysplasia. However, many dysplastic lesions were located separately from the carcinoma. The frequency of appearance of the dysplasia near the CIS was low (11%), demonstrating a negative dysplasia-CIS sequence in many of the esophageal cancers. Lymphocytic infiltration was investigated further beneath the dysplasia or CIS. The degree of lymphocytic infiltration with lymphoid follicles correlated with the severity of dysplasia and was the highest in CIS.
M Nagamatsu; M Mori; H Kuwano; K Sugimachi; T Akiyoshi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cancer     Volume:  69     ISSN:  0008-543X     ISO Abbreviation:  Cancer     Publication Date:  1992 Mar 
Date Detail:
Created Date:  1992-03-25     Completed Date:  1992-03-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0374236     Medline TA:  Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1094-8     Citation Subset:  AIM; IM    
Division of Clinical Pathology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
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MeSH Terms
Adenocarcinoma / pathology*
Carcinoma in Situ / pathology*
Carcinoma, Squamous Cell / pathology*
Esophageal Neoplasms / pathology*
Esophagus / pathology*
Lymphocytes, Tumor-Infiltrating / pathology
Neoplasm Invasiveness / pathology

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