Document Detail

Serial follow-up of adults with repaired tetralogy of Fallot.
MedLine Citation:
PMID:  1634663     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES AND BACKGROUND: Sudden death has long been considered a major contributor to mortality in pediatric patients with corrected tetralogy of Fallot. However, this may not apply to the patient with repaired tetralogy of Fallot who has survived into adulthood. Consequently we followed up a cohort of such adults to establish the clinical outcome and risk factors affecting their survival. METHODS: A baseline group of 151 adult patients with repaired tetralogy of Fallot were followed up for a mean of 3.2 years. The overall mortality rate was low (0.009 death/patient-year). Four patients died during follow-up, but only two deaths can be attributed to tetralogy of Fallot repair, and there were no sudden cardiac deaths. Clinically 94% of patients have remained in New York Heart Association functional class I. A subset of 36 patients were followed up for a mean of 6.7 years. This group had three sets of serial testing at 3-year intervals consisting of right heart catheterization at the initial study only, 24-h Holter ambulatory electrocardiographic (ECG) monitoring, exercise ECG and rest and exercise radionuclide angiography. RESULTS: Exercise capacity assessed by serial exercise stress testing remained stable over the follow-up period, whereas the presence of exercise-induced arrhythmias steadily decreased. Most patients had no significant arrhythmias and had no significant change in severity of arrhythmia with time. Radionuclide angiography showed significant improvement in exercise right ventricular ejection fraction over time but a progressive decrease in left ventricular ejection fraction at both rest and exercise. However, the left ventricular ejection fraction is still within the normal limits for our laboratory. CONCLUSIONS: Adults with repaired tetralogy of Fallot have a very good prognosis and a low risk of sudden death. However, ventricular function may change over time and should be carefully monitored.
S A Waien; P P Liu; B L Ross; W G Williams; G D Webb; P R McLaughlin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  20     ISSN:  0735-1097     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  1992 Aug 
Date Detail:
Created Date:  1992-08-21     Completed Date:  1992-08-21     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  295-300     Citation Subset:  AIM; IM    
Division of Cardiology, Toronto Hospital, University of Toronto, Ontario, Canada.
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MeSH Terms
Cohort Studies
Death, Sudden, Cardiac / epidemiology*
Electrocardiography, Ambulatory
Follow-Up Studies
Heart Catheterization
Radionuclide Angiography
Risk Factors
Survival Rate
Tetralogy of Fallot / diagnosis,  mortality,  surgery*
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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