| Serial first- and second-trimester Down's syndrome screening tests among IVF-versus naturally-conceived singletons. | |
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MedLine Citation:
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PMID: 11925409 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: It has been reported that second-trimester serum markers may be affected by assisted reproduction, leading to a higher false-positive rate. METHODS: A total of 285 naturally and 71 IVF-conceived singletons which underwent a serial disclosure Down's syndrome screening programme were compared. The study protocol included first-trimester combined [nuchal translucency (NT), free beta-HCG and pregnancy-associated plasma protein-A (PAPP-A)] testing. The second-trimester triple serum screening included alpha-fetoprotein (AFP), intact HCG and unconjugated estriol (uE3). After excluding aneuploidies, miscarriages, anatomical anomalies and cases with incomplete follow-up, the serum samples of normal cases were assessed and correlated. RESULTS: NT measurement was not significantly changed in either group. However, the IVF group had lower PAPP-A [0.96 versus 1.05 multiples of normal median (MoM)] and higher AFP (1.13 versus 1.07 median MoM). Both groups had similar rates of first-trimester false-positive results (FPR; 7 and 9% respectively), but the IVF group had a significantly higher mid-gestation FPR rate (10 versus 5%; Pearson chi2, P = 0.029). This has contributed to amniocentesis uptake rates of 15 and 13% for the IVF and natural conception pregnancies respectively. CONCLUSIONS: The IVF group tended to have a significantly higher second-trimester FPR rate. To counterbalance this phenomenon, integrated first- and second-trimester screening tests or the use of NT alone might be a reasonable option that deserves further investigation. |
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Authors:
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R Maymon; A Shulman |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Human reproduction (Oxford, England) Volume: 17 ISSN: 0268-1161 ISO Abbreviation: Hum. Reprod. Publication Date: 2002 Apr |
Date Detail:
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Created Date: 2002-04-01 Completed Date: 2002-10-09 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8701199 Medline TA: Hum Reprod Country: England |
Other Details:
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Languages: eng Pagination: 1081-5 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Assaf Harofe Medical Center, Zerifin, Israel. intposgr@post.tau.ac.il |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Down Syndrome / diagnosis*, embryology False Positive Reactions Female Fertilization* Fertilization in Vitro* Humans Longitudinal Studies Pregnancy Pregnancy Trimester, First Pregnancy Trimester, Second Pregnancy-Associated Plasma Protein-A / analysis* Prenatal Diagnosis / methods*, standards Reference Values alpha-Fetoproteins / analysis |
| Chemical | |
Reg. No./Substance:
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0/alpha-Fetoproteins; EC 3.4.24.-/Pregnancy-Associated Plasma Protein-A |
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