| Serial ferritin concentrations in hemodialysis patients receiving intravenous iron. | |
| | |
MedLine Citation:
|
PMID: 12078949 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Treatment of the anemia of chronic renal failure with intravenous iron and erythropoietin is highly effective, but frequently leads to ferritin levels which are much higher than those seen in the general population. High ferritin concentrations raise concern about the potential toxicity of increased body iron stores. PATIENTS AND METHODS: We retrospectively evaluated parameters of iron metabolism over a 4-year period among all our chronic hemodialysis patients who had been receiving intravenous iron and erythropoietin. Initially, patients received intermittent infusions of 300 mg intravenous iron x 3 doses for a low ferritin or low percent saturation of total iron binding capacity (TIBC), but this protocol was subsequently changed to weekly or biweekly infusions of 50-100 mg. RESULTS: We observed an improvement in average hemoglobin values, modest increases in serum iron and saturation of iron binding capacity, and a 125% increase in ferritin levels over 4 years. TIBC decreased. Overall, ferritin values increased 79 microg/l for each 1% increase in TIBC saturation. Ten patients with ferritin concentration greater than 1,000 pg/l received a three month course of vitamin C with no decline in the ferritin concentration. CONCLUSION: Current protocols for iron delivery may result in progressive increases in ferritin levels. Concern about the risks of iron overload should temper the quantity of iron used in dialysis programs. |
| | |
Authors:
|
B Kirschbaum |
Related Documents
:
|
15876809 - Intravenous iron therapy as a possible risk factor for atherosclerosis in end-stage ren... 22488009 - S-guanylation of human serum albumin is a unique posttranslational modification and res... 3005669 - The effect of antacids on the absorption of simultaneously ingested iron. 12453079 - Serum ferritin levels and early prognosis of stroke. 9448829 - Erythroid hypoplasia and anemia following administration of recombinant human erythropo... 16378319 - Stability of first- and second-trimester serum markers after storage and shipment. 1587939 - The synergistic effects of clomiphene citrate and human menopausal gonadotrophin in the... 6850819 - Histamine release from leucocytes in migraine. 17543719 - Hypogonadotropic hypogonadism. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Clinical nephrology Volume: 57 ISSN: 0301-0430 ISO Abbreviation: Clin. Nephrol. Publication Date: 2002 Jun |
Date Detail:
|
Created Date: 2002-06-24 Completed Date: 2002-12-13 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0364441 Medline TA: Clin Nephrol Country: Germany |
Other Details:
|
Languages: eng Pagination: 452-6 Citation Subset: IM |
Affiliation:
|
Division of Nephrology, Virginia Commonwealth University, Richmond 23298, USA. bkirschb@hsc.vcu.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Anemia
/
blood*,
drug therapy*,
etiology Erythropoietin / therapeutic use Ferritins / blood* Humans Infusions, Intravenous Iron / administration & dosage, adverse effects, therapeutic use* Iron Overload / blood, chemically induced Kidney Failure, Chronic / blood*, complications, therapy* Renal Dialysis* Retrospective Studies Time Factors |
| Chemical | |
Reg. No./Substance:
|
11096-26-7/Erythropoietin; 7439-89-6/Iron; 9007-73-2/Ferritins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The mature form of adrenomedullin correlates with brain natriuretic peptide in plasma of chronic hem...
Next Document: Intravenous iron administration does not significantly increase the risk of bacteremia in chronic he...