Document Detail

Serial epilepsy caused by levodopa/carbidopa administration in two patients on hemodialysis.
MedLine Citation:
PMID:  2265898     Owner:  NLM     Status:  MEDLINE    
Two patients with similar clinical features are presented: both patients had chronic renal failure, on hemodialysis for many years but recently begun on a high-flux dialyzer; both had been receiving a carbidopa/levodopa preparation; and both had the onset of hallucinosis and recurrent seizures, which were refractory to anticonvulsants. The first patient died without a diagnosis; the second patient had a dramatic recovery following the administration of vitamin B6. Neither patient was considered to have a renal state sufficiently severe enough to explain their presentation.
C R Bamford; D J Highkin; R Sandyk; T Travis; S Lee; F Torres; G Auerbach
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The International journal of neuroscience     Volume:  50     ISSN:  0020-7454     ISO Abbreviation:  Int. J. Neurosci.     Publication Date:  1990 Feb 
Date Detail:
Created Date:  1991-02-08     Completed Date:  1991-02-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0270707     Medline TA:  Int J Neurosci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  209-14     Citation Subset:  IM    
Department of Neurology, College of Medicine, University of Arizona, Tucson 85724.
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MeSH Terms
Carbidopa / administration & dosage,  adverse effects*
Epilepsy / chemically induced*
Kidney Failure, Chronic / therapy
Levodopa / administration & dosage,  adverse effects*
Middle Aged
Renal Dialysis*
Reg. No./Substance:
0/Levodopa; 38821-49-7/Carbidopa

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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