Document Detail

Serial diffusion tensor imaging to characterize radiation-induced changes in normal-appearing white matter following radiotherapy in patients with adult low-grade gliomas.
MedLine Citation:
PMID:  18683569     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The aim of this study was to ascertain whether diffusion tensor imaging (DTI) metrics fractional anisotropy (FA), mean diffusivity (MD), linear case (CL), planar case (CP), spherical case (CS)-can characterize a threshold dose and temporal evolution of changes in normal-appearing white matter (NAWM) of adults with low-grade gliomas (LGGs) treated with radiation therapy (RT). METHODS AND MATERIALS: Conventional and DTI imaging were performed before RT in 5 patients and subsequently, on average, at 3 months (n = 5), 8 months (n = 3), and 14 months (n = 5) following RT for a total of 18 examinations. Isodose distribution at 5-Gy intervals were visualized in all the slices of fluid attenuated inversion recovery (FLAIR) and the corresponding DTI images without diffusion sensitization (b0DTI). The latter were exported for relative quantitative analysis. RESULTS: Compared to pre-RT values, FA and CL decreased, whereas CS increased at 3 and 8 months and recovered partially at 14 months for the dose bins >55 Gy and 50-55 Gy. For the 45 50 Gy bin, the FA and CL decreased with an increase in CS at 3 months; no further change was seen at 8 or 14 months. For the >55 Gy and 50-55 Gy bins, CP decreased and MD increased at 3 months and returned to baseline at 8 months following RT. CONCLUSION: Radiation-induced changes in NAWM can be detected at 3 months after RT, with changes in FA, CL, and CS (but not CP or MD) values seen at a threshold dose of 45-50 Gy. A partial recovery was evident by 14 months to regions that received doses of 50-55 Gy and >55 Gy, thus providing an objective measure of radiation effect on NAWM.
Mohammad Haris; Shaleen Kumar; Mani Karthick Raj; Koilpillai Joseph Maria Das; Shantanu Sapru; Sanjay Behari; Ram Kishore Singh Rathore; Ponnada A Narayana; Rakesh Kumar Gupta
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Radiation medicine     Volume:  26     ISSN:  0288-2043     ISO Abbreviation:  Radiat Med     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-08-07     Completed Date:  2008-09-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8412264     Medline TA:  Radiat Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  140-50     Citation Subset:  IM    
Department of Radiodiagnosis, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareily Road, Lucknow 226014, India.
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MeSH Terms
Analysis of Variance
Brain Neoplasms / pathology,  radiotherapy*
Diffusion Magnetic Resonance Imaging*
Dose-Response Relationship, Radiation
Glioma / pathology,  radiotherapy*
Image Interpretation, Computer-Assisted
Nerve Fibers, Myelinated / radiation effects*
Radiation Injuries / diagnosis*
Radiotherapy Dosage

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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