Document Detail


Serial changes in oxidized low-density lipoprotein associated with culprit vessel in ST-elevation myocardial infarction--a promising marker?
MedLine Citation:
PMID:  19480313     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of the present study was to investigate variations in oxidized LDL (oxLDL) at the onset of acute myocardial infarction (AMI) and over the recovery period, exploring their relationship with coronary disease severity. A follow-up of 50 AMI patients was evaluated against 25 healthy volunteers (reference group). The AMI patients were evaluated at three time points: at admission before the administration of IIb/IIIa inhibitors and angioplasty, and two and 40 days after intervention. Plasma oxLDL concentrations were measured by ELISA. oxLDL was found to be significantly higher in AMI patients in the acute phase relative to reference levels, decreasing progressively over the recovery period. The results also demonstrated that oxLDL levels were decreased in patients with the left circumflex artery (LCX) as culprit vessel compared to the left anterior descending coronary (LAD) or right coronary artery (RCA). The results highlight a significant increase in oxLDL concentration related to coronary artery disease severity, as conditions such as LCX lesions are usually associated with a favorable prognosis, contrasting with LAD-associated conditions that can compromise large areas of myocardium. The results thus suggest that oxLDL may constitute a promising marker in assessment of AMI evolution.
Authors:
Patrícia Napoleão; Mafalda Selas; Alexandra Toste; Antónia Turkman; Valeska Andreozzi; Ana Maria Viegas-Crespo; Teresa Pinheiro; Rui Cruz Ferreira
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Revista portuguesa de cardiologia : orgão oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology     Volume:  28     ISSN:  0870-2551     ISO Abbreviation:  Rev Port Cardiol     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-06-01     Completed Date:  2009-07-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8710716     Medline TA:  Rev Port Cardiol     Country:  Portugal    
Other Details:
Languages:  eng     Pagination:  303-8     Citation Subset:  IM    
Affiliation:
Centro de Biologia Ambiental, Universidade de Lisboa, Lisboa, Portugal. pnapoleao@itn.pt
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MeSH Terms
Descriptor/Qualifier:
Adult
Electrocardiography
Female
Follow-Up Studies
Humans
Lipoproteins, LDL / blood*
Longitudinal Studies
Male
Myocardial Infarction / blood*,  etiology,  physiopathology*
Chemical
Reg. No./Substance:
0/Lipoproteins, LDL; 0/oxidized low density lipoprotein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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