Document Detail


Serial changes in myocardial perfusion using tomographic technetium-99m-hexakis-2-methoxy-2-methylpropyl-isonitrile imaging following reperfusion therapy of myocardial infarction.
MedLine Citation:
PMID:  2143527     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Resting tomographic myocardial perfusion images using technetium-99m-hexakis-2-methoxy-2-methylpropyl-isonitrile (Tc-Sestamibi) were obtained in 25 patients during their first myocardial infarction. Tc-Sestamibi was injected intravenously before acute reperfusion therapy, and repeated twice, at 18-48 hr, and at 6 to 14 days. Reperfusion was successful in 19 patients. In the patients with successful reperfusion, there was a mean decrease in the amount of hypoperfused myocardium between the initial and second studies (-9% +/- 12%, p = 0.004) and a further decrease between the second and final studies (-10% +/- 12%, p = 0.002). Nine of these 19 patients (47%) had evidence of significant improvement at the time of the second study. In six patients, significant improvement was not evident until the final study. Although tomographic imaging with Tc-Sestamibi following reperfusion therapy may show improvement in perfusion at 18-48 hr, the full extent of improvement is usually not evident until later.
Authors:
P A Pellikka; T Behrenbeck; M S Verani; J J Mahmarian; F J Wackers; R J Gibbons
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of nuclear medicine : official publication, Society of Nuclear Medicine     Volume:  31     ISSN:  0161-5505     ISO Abbreviation:  J. Nucl. Med.     Publication Date:  1990 Aug 
Date Detail:
Created Date:  1990-09-18     Completed Date:  1990-09-18     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0217410     Medline TA:  J Nucl Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1269-75     Citation Subset:  IM    
Affiliation:
Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Coronary Circulation*
Evaluation Studies as Topic
Female
Humans
Male
Middle Aged
Myocardial Infarction / physiopathology,  radionuclide imaging*,  surgery
Myocardial Reperfusion
Nitriles / diagnostic use*
Organotechnetium Compounds / diagnostic use*
Technetium Tc 99m Sestamibi
Time Factors
Chemical
Reg. No./Substance:
0/Nitriles; 0/Organotechnetium Compounds; 109581-73-9/Technetium Tc 99m Sestamibi

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