| Serial changes in left ventricular shape following early mitral valve repair. | |
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MedLine Citation:
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PMID: 20816125 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mitral valve (MV) repair has become the preferred treatment for mitral regurgitation associated with degenerative MV disease. Although the functional benefits of early MV repair are known, the associated alterations in left ventricular (LV) shape have not been studied. The aim of this study was to evaluate serial changes in LV performance and 3-dimensional (3D) shape after MV repair using a new analytic technique. Fifty patients (mean age 59 +/- 12 years) with severe asymptomatic mitral regurgitation and ejection fractions >55% who underwent MV repair were enrolled. Transthoracic real-time 3D echocardiography was performed the day before and 6 and 12 months after MV repair. An age-matched control group of 50 normal subjects was studied for comparison. Endocardial surfaces were extracted to compute 3D shape indexes of sphericity and conicity, which were compared in patients between different time points and versus the normal group. Postoperatively, LV volumes were decreased compared to presurgical values. Ejection fractions were slightly decreased 6 months after surgery but had restored by 12 months. These changes were associated with modifications in end-diastolic LV shape: before surgery, compared to normal controls, sphericity was augmented and conicity was decreased; at 6 months, these shape changes were reversed, with no further improvements at 12 months. In conclusion, patients with asymptomatic mitral regurgitation and preserved LV function already exhibit changes in LV shape. Early MV repair leads to near normal morphology after surgery, indicating the benefits of this procedure. Real-time 3D echocardiography and novel 3D shape analysis allow detailed serial examination of the complex relation between LV performance and shape. |
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Authors:
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Francesco Maffessanti; Enrico G Caiani; Gloria Tamborini; Manuela Muratori; Lissa Sugeng; Lynn Weinert; Francesco Alamanni; Marco Zanobini; Victor Mor-Avi; Roberto M Lang; Mauro Pepi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-08-02 |
Journal Detail:
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Title: The American journal of cardiology Volume: 106 ISSN: 1879-1913 ISO Abbreviation: Am. J. Cardiol. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-06 Completed Date: 2010-09-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 836-42 Citation Subset: AIM; IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Biomedical Engineering, Politecnico di Milano, Milan, Italy. francesco.maffessanti@mail.polimi.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Cardiac Surgical Procedures / methods Case-Control Studies Female Heart Ventricles / pathology, physiopathology, surgery*, ultrasonography* Humans Male Middle Aged Mitral Valve Insufficiency / diagnosis, physiopathology, surgery*, ultrasonography* Postoperative Period Predictive Value of Tests Preoperative Period Sensitivity and Specificity Severity of Illness Index Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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