Document Detail

Serial beta-subunit human chorionic gonadotropin doubling time as a prognosticator of pregnancy outcome in an infertile population.
MedLine Citation:
PMID:  7202754     Owner:  NLM     Status:  MEDLINE    
Prospective evaluation through the use of radioimmunoassay of the beta-subunit of human chorionic gonadotropin (beta-hCG) in blood samples obtained during the first 30 days of gestation was performed on an infertile population at high risk for pregnancy loss. Four hundred and fourteen samples in 281 pregnancies were analyzed. On the basis of single, random beta-hCG samples in asymptomatic patients, 77% of successful pregnancies and 59% of abortions were correctly identified. On the basis of beta-hCG doubling time (mean 2.2 days +/- 1.0 [2 SD]) computed from serial sampling, again in asymptomatic patients, 88% of successful pregnancies and 76% of abortions were correctly identified. beta-hCG doubling time appears to provide a reliable method of evaluating early pregnancy prognosis with significantly greater ability to identify problem pregnancies within the first 30 days of gestation than does single random hCG values.
F R Batzer; S Schlaff; A F Goldfarb; S L Corson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Fertility and sterility     Volume:  35     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  1981 Mar 
Date Detail:
Created Date:  1981-05-21     Completed Date:  1981-05-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  307-12     Citation Subset:  IM    
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MeSH Terms
Abortion, Incomplete / diagnosis
Chorionic Gonadotropin / blood*
Infertility, Female / diagnosis*
Pregnancy, Multiple
Time Factors
Trophoblasts / cytology
Reg. No./Substance:
0/Chorionic Gonadotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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