Document Detail


Serial analysis of stable nitrogen and carbon isotopes in hair: monitoring starvation and recovery phases of patients suffering from anorexia nervosa.
MedLine Citation:
PMID:  16628564     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Stable nitrogen and carbon isotopic ratios of hair strands of six patients suffering from anorexia nervosa were measured to monitor a dietary change from near starvation to recovery. This paper presents the results of a first-time study of nitrogen and carbon balance of the patients prior to and after admittance to a hospital and therapy. Sequential analysis of the isotopic ratios of hair strands of all patients could be related to the respective body mass index (BMI) of each patient. Our hypothesis concerning the diachronic change in delta15N and delta13C during therapy was met: The delta15N values were inversely related to the BMI, indicating a slow-down in catabolism of bodily protein due to the process of gluconeogenesis during the starvation phase. In contrast, the delta13C values and BMI were in phase: an increase in BMI resulted in an increase in the delta13C values. This rise in delta13C ratios is best interpreted by an increased supply of protein in the diet. Furthermore, delta15N and delta13C were inversely related. We conclude that hair, which is easily and non-traumatically sampled, is an adequate monitor that reflects dietary change and nitrogen balance within days. This isotopic method may also be applied in forensic studies with regard to cases of deprivation, and starvation, and may be a method for investigating starvation in historic populations.
Authors:
Anna-Maria Mekota; Gisela Grupe; Sandra Ufer; Ullrich Cuntz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Rapid communications in mass spectrometry : RCM     Volume:  20     ISSN:  0951-4198     ISO Abbreviation:  Rapid Commun. Mass Spectrom.     Publication Date:  2006  
Date Detail:
Created Date:  2006-05-08     Completed Date:  2007-07-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8802365     Medline TA:  Rapid Commun Mass Spectrom     Country:  England    
Other Details:
Languages:  eng     Pagination:  1604-10     Citation Subset:  IM    
Copyright Information:
Copyright 2006 John Wiley & Sons, Ltd.
Affiliation:
Biodiversity/Anthropology, Ludwig-Maximilians-University, Munich, 82152 Martinsried, Germany. a.mekota@lrz.uni-muenchen.de
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MeSH Terms
Descriptor/Qualifier:
Adult
Anorexia Nervosa / metabolism*
Body Mass Index
Carbon Isotopes / analysis
Diet
Female
Gluconeogenesis
Hair / chemistry*
Humans
Keratins / analysis
Male
Nitrogen Isotopes / analysis
Soaps
Starvation / metabolism*
Chemical
Reg. No./Substance:
0/Carbon Isotopes; 0/Nitrogen Isotopes; 0/Soaps; 68238-35-7/Keratins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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