Document Detail


Serial analysis of gene expression in the frontal cortex of patients with bipolar disorder.
MedLine Citation:
PMID:  11450174     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Bipolar disorder is a serious brain disease affecting more than a million individuals living in the USA. Epidemiological studies indicate a role for both genetic and environmental factors in the pathogenesis of this disorder. AIM: To identify RNA transcripts that are up- or down-regulated in the frontal cortex regions of individuals with bipolar disorder. METHOD: Serial analysis of gene expression (SAGE) and reverse transcriptase-polymerase chain reaction were used to identify RNA transcripts which are differentially expressed in the frontal cortex of brains obtained postmortem from individuals with bipolar disorder compared with other psychiatric and control conditions. RESULTS: Levels of RNA transcripts encoding the serotonin transporter protein and components of the NF-kappa B transcription factor complex are significantly increased in individuals with bipolar disorder compared with unaffected controls. Increased levels of expression of these RNA transcripts were also detected in the brains of some individuals with schizophrenia and unipolar depression. CONCLUSION: The SAGE technique offers promise for the characterisation of complex human brain diseases.
Authors:
Y Sun; L Zhang; N L Johnston; E F Torrey; R H Yolken
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of psychiatry. Supplement     Volume:  41     ISSN:  0960-5371     ISO Abbreviation:  Br J Psychiatry Suppl     Publication Date:  2001 Jun 
Date Detail:
Created Date:  2001-07-13     Completed Date:  2001-07-26     Revised Date:  2008-02-22    
Medline Journal Info:
Nlm Unique ID:  9001294     Medline TA:  Br J Psychiatry Suppl     Country:  England    
Other Details:
Languages:  eng     Pagination:  s137-41     Citation Subset:  IM    
Affiliation:
Stanley Division of Developmental Neurovirology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
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MeSH Terms
Descriptor/Qualifier:
Bipolar Disorder / metabolism*
Carrier Proteins / genetics,  metabolism
Cerebral Cortex / metabolism*
Gene Expression
Humans
Membrane Glycoproteins / genetics,  metabolism
Membrane Transport Proteins*
NF-kappa B / genetics,  metabolism
Nerve Tissue Proteins / genetics,  metabolism
RNA / genetics
Reverse Transcriptase Polymerase Chain Reaction
Serotonin Plasma Membrane Transport Proteins
Transcription, Genetic
Chemical
Reg. No./Substance:
0/Carrier Proteins; 0/Membrane Glycoproteins; 0/Membrane Transport Proteins; 0/NF-kappa B; 0/Nerve Tissue Proteins; 0/SLC6A4 protein, human; 0/Serotonin Plasma Membrane Transport Proteins; 63231-63-0/RNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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