| Serial analysis of gene expression in the frontal cortex of patients with bipolar disorder. | |
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MedLine Citation:
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PMID: 11450174 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Bipolar disorder is a serious brain disease affecting more than a million individuals living in the USA. Epidemiological studies indicate a role for both genetic and environmental factors in the pathogenesis of this disorder. AIM: To identify RNA transcripts that are up- or down-regulated in the frontal cortex regions of individuals with bipolar disorder. METHOD: Serial analysis of gene expression (SAGE) and reverse transcriptase-polymerase chain reaction were used to identify RNA transcripts which are differentially expressed in the frontal cortex of brains obtained postmortem from individuals with bipolar disorder compared with other psychiatric and control conditions. RESULTS: Levels of RNA transcripts encoding the serotonin transporter protein and components of the NF-kappa B transcription factor complex are significantly increased in individuals with bipolar disorder compared with unaffected controls. Increased levels of expression of these RNA transcripts were also detected in the brains of some individuals with schizophrenia and unipolar depression. CONCLUSION: The SAGE technique offers promise for the characterisation of complex human brain diseases. |
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Authors:
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Y Sun; L Zhang; N L Johnston; E F Torrey; R H Yolken |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The British journal of psychiatry. Supplement Volume: 41 ISSN: 0960-5371 ISO Abbreviation: Br J Psychiatry Suppl Publication Date: 2001 Jun |
Date Detail:
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Created Date: 2001-07-13 Completed Date: 2001-07-26 Revised Date: 2008-02-22 |
Medline Journal Info:
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Nlm Unique ID: 9001294 Medline TA: Br J Psychiatry Suppl Country: England |
Other Details:
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Languages: eng Pagination: s137-41 Citation Subset: IM |
Affiliation:
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Stanley Division of Developmental Neurovirology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Bipolar Disorder
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metabolism* Carrier Proteins / genetics, metabolism Cerebral Cortex / metabolism* Gene Expression Humans Membrane Glycoproteins / genetics, metabolism Membrane Transport Proteins* NF-kappa B / genetics, metabolism Nerve Tissue Proteins / genetics, metabolism RNA / genetics Reverse Transcriptase Polymerase Chain Reaction Serotonin Plasma Membrane Transport Proteins Transcription, Genetic |
| Chemical | |
Reg. No./Substance:
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0/Carrier Proteins; 0/Membrane Glycoproteins; 0/Membrane Transport Proteins; 0/NF-kappa B; 0/Nerve Tissue Proteins; 0/SLC6A4 protein, human; 0/Serotonin Plasma Membrane Transport Proteins; 63231-63-0/RNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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