Document Detail

Serial analysis of circulating T gamma/delta lymphocyte subpopulations in Graves' disease.
MedLine Citation:
PMID:  9738704     Owner:  NLM     Status:  MEDLINE    
In the present paper the distribution of peripheral blood T gamma/delta lymphocytes in Graves' disease patients is analyzed in order to correlate them with disease activity and with prognosis. Eighteen patients with Graves' disease, 24 patients with Hashimoto's thyroiditis and 32 sex- and age-matched healthy control subjects were studied. Peripheral blood CD3+ alpha/beta and gamma/delta T lymphocytes as well as CD4+ and CD8+ T cells, and CD19 (B) lymphocytes were analyzed by cytofluorometry. At diagnosis, patients who required a radical treatment for thyrotoxicosis control showed a significant decrease of T gamma/delta lymphocytes and an increase of B cells when compared with those who maintained the euthyroid state after methimazole. No correlation was detected between the percentages of these subpopulations and serum free thyroxine. This decreased proportion did not normalize after methimazole or radical treatments. These results suggest that the cytotoxic T gamma/delta compartment of the immune system is altered in patients with Graves' disease.
S Sasián; J Rojano; I Gavilán; M Aguilar; L Escobar; J A Girón
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Endocrine research     Volume:  24     ISSN:  0743-5800     ISO Abbreviation:  Endocr. Res.     Publication Date:  1998 May 
Date Detail:
Created Date:  1998-11-19     Completed Date:  1998-11-19     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8408548     Medline TA:  Endocr Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  285-95     Citation Subset:  IM    
Service of Internal Medicin, Hospital Universitario Puerta del Mar, Facultad de Medicina, Cádiz, Spain.
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MeSH Terms
Antigens, CD / analysis
Autoantibodies / blood
B-Lymphocytes / immunology
Graves Disease / immunology*
Immunoglobulins, Thyroid-Stimulating
Middle Aged
Receptors, Antigen, T-Cell, gamma-delta / analysis*
Receptors, Thyrotropin / blood
T-Lymphocyte Subsets / immunology*
Thyroglobulin / immunology
Thyroid Gland / immunology
Thyroiditis, Autoimmune / immunology
Thyroxine / blood
Triiodothyronine / blood
Reg. No./Substance:
0/Antigens, CD; 0/Autoantibodies; 0/Immunoglobulins, Thyroid-Stimulating; 0/Receptors, Antigen, T-Cell, gamma-delta; 0/Receptors, Thyrotropin; 0/anti-thyroglobulin; 0/thyrotropin-binding inhibitory immunoglobulin; 6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine; 9010-34-8/Thyroglobulin

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