Document Detail


Serial ultrasound evaluation of intramyocardial strain after reperfused myocardial infarction reveals that remote zone dyssynchrony develops in concert with left ventricular remodeling.
MedLine Citation:
PMID:  21640480     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study noninvasively evaluated the development of left ventricular (LV) dyssynchrony following reperfused myocardial infarction (MI) in mice using an ultrasonic speckle-tracking method. Eight C57BL/6J mice were assessed by high-resolution echocardiography at baseline and at eight time-points following MI. Images were acquired at 1mm elevational intervals encompassing the entire LV to determine chamber volumes and radial strain. Receiver-operating characteristic (ROC) analysis of regional radial strain was used to segment the three-dimensional (3-D) LV into infarct, adjacent and remote zones. This in vivo segmentation was correlated to histologic infarct size (R = 0.89, p < 0.01) in a short-axis, slice-by-slice comparison. The onset of dyssynchrony during LV remodeling was assessed by standard deviation of time to peak radial strain in the infarct, adjacent and remote zones. It was discovered that the form of LV dyssynchrony that develops in the remote zone late after MI does so in concert with the progression of LV remodeling (R = 0.70, p < 0.05).
Authors:
Yinbo Li; Christopher D Garson; Yaqin Xu; Patrick A Helm; John A Hossack; Brent A French
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-06-02
Journal Detail:
Title:  Ultrasound in medicine & biology     Volume:  37     ISSN:  1879-291X     ISO Abbreviation:  Ultrasound Med Biol     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-06-20     Completed Date:  2011-11-01     Revised Date:  2014-09-22    
Medline Journal Info:
Nlm Unique ID:  0410553     Medline TA:  Ultrasound Med Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1073-86     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Disease Progression
Echocardiography / methods*
Imaging, Three-Dimensional
Male
Mice
Mice, Inbred C57BL
Myocardial Infarction / physiopathology*,  ultrasonography*
Myocardial Reperfusion
Photomicrography
ROC Curve
Ventricular Dysfunction, Left / physiopathology*,  ultrasonography*
Ventricular Remodeling*
Grant Support
ID/Acronym/Agency:
EB001826/EB/NIBIB NIH HHS; R01 EB001826/EB/NIBIB NIH HHS; R01 EB001826-07/EB/NIBIB NIH HHS; R01 HL058582/HL/NHLBI NIH HHS; R01 HL058582-07/HL/NHLBI NIH HHS; R01HL058582/HL/NHLBI NIH HHS; RR022582/RR/NCRR NIH HHS; S10 RR022582/RR/NCRR NIH HHS; S10 RR022582-01/RR/NCRR NIH HHS; S10 RR027333/RR/NCRR NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Transcatheter Arterial Chemoembolization in Combination With High-Intensity Focused Ultrasound for U...
Next Document:  A Novel 3-D Power Doppler Ultrasound Approach to the Quantification of Achilles Tendon Neovascularit...