| Serial plasma levels of angiogenic factors in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. | |
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MedLine Citation:
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PMID: 22870080 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND OBJECTIVES: Patients with acute myocardial infarction show varying degrees of collateral development. However, the relationships between angiogenic factors and degree of collaterals are not well known. SUBJECTS AND METHODS: Fifty-nine patients (mean age, 59±10 years) with ST-segment elevation myocardial infarction (STEMI) underwent primary percutaneous coronary intervention (PCI). Patients were divided into one of 2 groups: group I (Rentrop collateral grade 0/1, n=34) or group II (grade 2/3, n=25). Plasma levels of vascular endothelial growth factor (VEGF), soluble VEGF receptor (sFlt-1), angiopoietin (Ang)-2, and soluble Tie-2 at baseline, 24 and 48 hours after PCI were measured. RESULTS: There were fewer diabetic patients and higher incidence of previous angina and multi-vessel disease in group II. Group II had a lower left ventricular ejection fraction and a trend toward longer pain-to-balloon time. Plasma levels of Ang-2, sFlt-1 were elevated prior to primary PCI and decreased after PCI, whereas plasma level of VEGF was relatively low initially, however rose after PCI. sTie-2 levels showed no significant interval change in group I, but decreased over time in group II. VEGF, sFlt-1, and Tie-2 levels did not differ between the groups at each time point. However, plasma levels of Ang-2 were higher in group I than in group II at baseline and at 48 hours. CONCLUSION: Presence of collaterals in STEMI patients undergoing primary PCI was associated with lesser rise in Ang-2 plasma level. VEGF showed a delayed response to acute ischemia compared to Ang-2. Clinical implications of our findings need to be investigated in further studies. |
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Authors:
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Bo Hyun Kim; Young-Guk Ko; Ae-Young Her; Jung-Sun Kim; Ki-Chul Hwang; Dong-Ho Shin; Byeong-Keuk Kim; Donghoon Choi; Jong-Won Ha; Myeong-Ki Hong; Yangsoo Jang |
Publication Detail:
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Type: Journal Article Date: 2012-07-26 |
Journal Detail:
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Title: Korean circulation journal Volume: 42 ISSN: 1738-5555 ISO Abbreviation: Korean Circ J Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-08-07 Completed Date: 2012-08-08 Revised Date: 2012-08-09 |
Medline Journal Info:
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Nlm Unique ID: 101247141 Medline TA: Korean Circ J Country: Korea (South) |
Other Details:
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Languages: eng Pagination: 464-70 Citation Subset: - |
Affiliation:
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Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University Health System, Seoul, Korea. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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