Document Detail

Serial perfusion study depicts pulmonary vascular growth in the survivors of non-extracorporeal membrane oxygenation-treated congenital diaphragmatic hernia.
MedLine Citation:
PMID:  20414002     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Pulmonary growth in the survivors of congenital diaphragmatic hernia (CDH) still remains an intriguing issue. In the literature there are conflicting reports on pulmonary vascular growth in CDH.
OBJECTIVE: In a cohort of CDH patients treated without extracorporeal membrane oxygenation (ECMO), serial perfusion studies were conducted prospectively to follow the growth of pulmonary vasculature.
MATERIAL AND METHODS: Survivors of CDH repair between January 2000 and January 2003 were studied prospectively. Patient demography, time of presentation, arterioalveolar oxygen gradient (A-aDO(2)), time to complete lung expansion, and respiratory symptoms were noted. Lung perfusion studies were done at 3 months, 9 months, and 6 years of follow-up.
RESULTS: 24 neonates completed the study. Mean presentation was 6.9 h, and preoperative A-aDO(2) was 288.8. 16/24 were managed by conventional ventilation and 8/24 required high-frequency ventilation and nitric oxide therapy (none were treated with ECMO). Mean duration of preoperative stabilization was 26.5 h, time to full lung expansion was 2.8 days, and postoperative ventilation was 3.7 days. Mean perfusion (%) of ipsilateral lung was 33.7% at 3 months, 43.2% at 9 months, and 46.8% at 6 years. Perfusion of ipsilateral lung improved by 9.4% from 3 to 9 months (p < 0.001), 13.1% from 3 months to 6 years (p < 0.001), and 3.7% from 9 months to 6 years postoperatively (p < 0.001). Respiratory symptoms were seen in 45% (11/24) of survivors at 3 months, 14% (4/24) at 9 months, and 12.5% (3/24) at 6 years postoperatively.
CONCLUSIONS: There was reduced perfusion of affected lung at 3 months which improved significantly at 9 months and at 6 years. Recovery of pulmonary vascular function correlated with amelioration of respiratory symptoms. The majority of survivors showing a significant vascular growth lead a symptom-free life.
Kamalesh Pal; D K Gupta
Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2010-04-23
Journal Detail:
Title:  Neonatology     Volume:  98     ISSN:  1661-7819     ISO Abbreviation:  Neonatology     Publication Date:  2010  
Date Detail:
Created Date:  2010-09-17     Completed Date:  2011-01-24     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  101286577     Medline TA:  Neonatology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  254-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 S. Karger AG, Basel.
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MeSH Terms
Blood Vessels / growth & development*
Cohort Studies
Extracorporeal Membrane Oxygenation
Follow-Up Studies
Hernia, Diaphragmatic / congenital*,  mortality,  surgery,  therapy*
Infant, Newborn
Infant, Newborn, Diseases / mortality,  surgery,  therapy
Lung / blood supply*,  growth & development
Perfusion / methods*
Perfusion Imaging
Respiratory Therapy / methods*
Severity of Illness Index

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