| Serial MRI in a case of familial hemiplegic migraine. | |
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MedLine Citation:
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PMID: 12669159 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report MRI findings in a patient with familial hemiplegic migraine (FHM) with repeated episodes of hemiparesis. FHM is caused by a penetrant autosomal dominant genetic mutation; several mutations have been genotyped, involving brain-expressed ion channels. We found cerebral oedema, dilatation of intracerebral vessels and decreased water diffusion contralateral to the hemiparesis, not respecting vascular territories, with subsequent complete resolution of both clinical and imaging abnormalities. These results are thought to be consistent with an underlying primary neuronal pathology with secondary vascular effects, as opposed to the traditional, primarily vascular, model of migraine aetiology. |
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Authors:
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D J A Butteriss; V Ramesh; D Birchall |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2003-03-27 |
Journal Detail:
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Title: Neuroradiology Volume: 45 ISSN: 0028-3940 ISO Abbreviation: Neuroradiology Publication Date: 2003 May |
Date Detail:
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Created Date: 2003-05-13 Completed Date: 2003-07-18 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 1302751 Medline TA: Neuroradiology Country: Germany |
Other Details:
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Languages: eng Pagination: 300-3 Citation Subset: IM |
Affiliation:
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Department of Neuroradiology, Regional Neurosciences Centre Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, NE4 6BE, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Brain / pathology* Hemiplegia / genetics*, pathology Humans Magnetic Resonance Imaging* Male Migraine Disorders / genetics*, pathology Mutation |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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