| Serial MRI and CSF Analysis in a Dog Treated with Intrathecal Amphotericin B for Protothecosis. | |
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MedLine Citation:
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PMID: 22267176 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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A 3 yr old female spayed English setter mixed-breed dog presented with diarrhea, weight loss, side stepping to the right, and a right head tilt. Rectal and cerebrospinal fluid cytology and culture confirmed a diagnosis of Prototheca zopfii. MRI of the brain showed inflammation of the brain and meninges, ventriculomegaly, and syringomyelia. Treatment with prednisone, itraconazole, and amphotericin B lipid complex administered intrathecally yielded transient improvement. Progressive brainstem signs were noted, and a repeat MRI and cerebrospinal fluid analysis documented persistent disease. This is the first description of the MRI findings and treatment with intrathecal amphoteracin B lipid complex for protothecosis of the central nervous system. Protothecosis should be considered in dogs with chronic diarrhea and compatible MRI findings. |
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Authors:
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Martin Young; William Bush; Melissa Sanchez; Pat Gavin; Mathew Williams |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-19 |
Journal Detail:
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Title: Journal of the American Animal Hospital Association Volume: - ISSN: 1547-3317 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0415027 Medline TA: J Am Anim Hosp Assoc Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Bush Veterinary Neurology Service, Leesburg, VA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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