| Serial CT and MRI findings in a patient with isolated angiitis of the central nervous system associated with cerebral amyloid angiopathy. | |
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MedLine Citation:
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PMID: 12557755 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report serial CT and MRI findings in a biopsy-proven case of cerebral amyloid angiopathy (CAA) with isolated angiitis of the central nervous system (CNS). A 69-year-old man had developed dizziness, dementia, and generalized seizure during the preceding 4 years. An initial examination by brain CT and MRI showed bilateral symmetrical periventricular lesions closely resembling those of Binswanger's disease. Subsequently, the lesions expanded slowly, involving a large area of the right cerebral hemisphere with an obvious mass effect. Since a primary brain tumor was suspected, a brain biopsy was performed, and histopathological examination revealed amyloid beta protein CAA within the meningocortical vessels associated with perivascular monocytic cuffing, indicating the presence of isolated angiitis of the CNS. Multinucleated giant cells containing intracytoplasmic beta protein amyloid around a heavily amyloid-laden cortical vessel were also observed. This is the first case report to show sequential radiographical studies of the leukoencephalopathy associated with CAA and isolated angiitis of the CNS. |
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Authors:
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Takashi Oide; Takahiko Tokuda; Yo-ichi Takei; Hitoshi Takahashi; Kenjiro Ito; Shu-ichi Ikeda |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis Volume: 9 ISSN: 1350-6129 ISO Abbreviation: Amyloid Publication Date: 2002 Dec |
Date Detail:
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Created Date: 2003-01-31 Completed Date: 2003-07-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9433802 Medline TA: Amyloid Country: United States |
Other Details:
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Languages: eng Pagination: 256-62 Citation Subset: IM |
Affiliation:
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Third Department of Medicine, Shinshu University School of Medicine, Matsumoto 390-8621, Nagano, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Central Nervous System Diseases / complications, diagnosis*, radiography Cerebral Amyloid Angiopathy / complications, diagnosis*, radiography Humans Magnetic Resonance Imaging Male Tomography, X-Ray Computed Vasculitis / complications, diagnosis*, radiography |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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