Document Detail


Sera of IgA nephropathy patients contain a heterogeneous population of relatively cationic alpha-heavy chains.
MedLine Citation:
PMID:  9546689     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sera of IgA nephropathy (IgAN) patients and normal subjects were analysed by two-dimensional (2-D) gel electrophoresis. Densitometric analysis of the 2-D gels of IgAN patients and normal subjects revealed that their protein maps were comparable. There was no shift of pI values in the major alpha-heavy chain spots. However, the volume of the alpha-heavy chain bands were differently distributed. Distribution was significantly lower at the anionic region in IgAN patients (mean anionic:cationic ratio of 1.184 +/- 0.311) as compared to normal healthy controls (mean anionic:cationic ratio of 2.139 +/- 0.538). Our data are in support of the previously reported findings that IgA1 of IgAN patients were lacking in sialic acid residues.
Authors:
A S Shuib; C T Chua; O H Hashim
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nephron     Volume:  78     ISSN:  0028-2766     ISO Abbreviation:  Nephron     Publication Date:  1998  
Date Detail:
Created Date:  1998-05-22     Completed Date:  1998-05-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0331777     Medline TA:  Nephron     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  290-5     Citation Subset:  IM    
Affiliation:
Department of Biochemistry, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
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MeSH Terms
Descriptor/Qualifier:
Adult
Blotting, Western
Cations
Densitometry / methods
Electrophoresis, Gel, Two-Dimensional / methods
Glomerulonephritis, IGA / blood*
Humans
Immunoglobulin Heavy Chains / blood*
Immunoglobulin alpha-Chains / blood*
Lectins
Middle Aged
Chemical
Reg. No./Substance:
0/Cations; 0/Immunoglobulin Heavy Chains; 0/Immunoglobulin alpha-Chains; 0/Lectins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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