Document Detail

Sequoia regulates cell fate decisions in the external sensory organs of adult Drosophila.
MedLine Citation:
PMID:  19444309     Owner:  NLM     Status:  MEDLINE    
The adult Drosophila external sensory organ (ESO), comprising the hair, socket, neuron, sheath and glia cells, arises through the asymmetric division of sensory organ precursor cells (SOPs). In a mosaic screen designed to identify new components in ESO development, we isolated mutations in sequoia, which encodes a putative zinc-finger transcription factor that has previously been shown to have a role in dendritogenesis. Here, we show that adult clones mutant for seq exhibit a loss of hair cells and a gain of socket cells. We propose that the seq mutant phenotype arises, in part, owing to the loss of several crucial transcription factors known to be important in peripheral nervous system development such as D-Pax2, Prospero and Hamlet. Thus, Sequoia is a new upstream regulator of genes that orchestrates cell fate specification during development of the adult ESO lineage.
Hillary K Andrews; Nikolaos Giagtzoglou; Shinya Yamamoto; Karen L Schulze; Hugo J Bellen
Related Documents :
16876109 - Separation of two cell signalling molecules from a symbiotic sponge that modify algal c...
7875369 - Cellular events during development of the olfactory sense organs in drosophila melanoga...
16099639 - Molecular control of cell polarity and asymmetric cell division in drosophila neuroblasts.
9107579 - The roles of preb cell receptor in early b cell development and its signal transduction.
17655839 - Differential control of cell affinity required for progression and refinement of cell b...
20861359 - Baff receptor signaling aids the differentiation of immature b cells into transitional ...
16876109 - Separation of two cell signalling molecules from a symbiotic sponge that modify algal c...
19903359 - Enhanced detection and study of murine norovirus-1 using a more efficient microglial ce...
21121359 - Nano titanium dioxide induces the generation of ros and potential damage in hacat cells...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2009-05-15
Journal Detail:
Title:  EMBO reports     Volume:  10     ISSN:  1469-3178     ISO Abbreviation:  EMBO Rep.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-06-08     Completed Date:  2009-08-13     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  100963049     Medline TA:  EMBO Rep     Country:  England    
Other Details:
Languages:  eng     Pagination:  636-41     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cell Lineage*
DNA-Binding Proteins / metabolism*
Drosophila Proteins / metabolism*
Drosophila melanogaster / cytology*,  metabolism*
Mutation / genetics
Nerve Tissue Proteins / metabolism*
Receptors, Notch / metabolism
Sense Organs / cytology*,  metabolism*
Signal Transduction
Grant Support
CA16672/CA/NCI NIH HHS; P30 HD024064/HD/NICHD NIH HHS; //Howard Hughes Medical Institute
Reg. No./Substance:
0/DNA-Binding Proteins; 0/Drosophila Proteins; 0/Nerve Tissue Proteins; 0/Receptors, Notch; 0/seq protein, Drosophila

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  A molecular trio in relapse and remission in multiple sclerosis.
Next Document:  COP9 signalosome controls the Carma1-Bcl10-Malt1 complex upon T-cell stimulation.