| Sequestration of a hepatocyte growth factor in extracellular matrix in normal adult rat liver. | |
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MedLine Citation:
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PMID: 1824922 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Perfusion of normal adult rat livers with Hanks' solution containing 1 M NaCl in situ led to the releasing of a large amount of hepatocyte growth factor (HGF). During the first 5 min of perfusion, the HGF content of the perfusate reached a maximum level, while the LDH activity due to release from the cells was negligible. The liver HGF content did not decrease with age. The liver HGF content in rats injured by CCl4 injection decreased temporarily and then recovered rapidly to a normal level. These results indicate that HGF is sequestered in the extracellular matrix in the subendothelial space in normal adult rat liver and its effect will be either neutralized or potentiated by other local factors. |
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Authors:
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A Masumoto; N Yamamoto |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 174 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 1991 Jan |
Date Detail:
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Created Date: 1991-02-22 Completed Date: 1991-02-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 90-5 Citation Subset: IM |
Affiliation:
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Department of Functional Morphology, School of Nursing Kitasato University, Kanagawa, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carbon Tetrachloride / pharmacology Cells, Cultured Extracellular Matrix / metabolism* Growth Substances / metabolism* Hepatocyte Growth Factor Kinetics L-Lactate Dehydrogenase / metabolism Liver / drug effects, enzymology, metabolism* Male Organ Size Perfusion Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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0/Growth Substances; 56-23-5/Carbon Tetrachloride; 67256-21-7/Hepatocyte Growth Factor; EC 1.1.1.27/L-Lactate Dehydrogenase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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