| Sequestration and Microvascular Congestion Are Associated With Coma in Human Cerebral Malaria. | |
| | |
MedLine Citation:
|
PMID: 22207648 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
The pathogenesis of coma in severe Plasmodium falciparum malaria remains poorly understood. Obstruction of the brain microvasculature because of sequestration of parasitized red blood cells (pRBCs) represents one mechanism that could contribute to coma in cerebral malaria. Quantitative postmortem microscopy of brain sections from Vietnamese adults dying of malaria confirmed that sequestration in the cerebral microvasculature was significantly higher in patients with cerebral malaria (CM; n = 21) than in patients with non-CM (n = 23). Sequestration of pRBCs and CM was also significantly associated with increased microvascular congestion by infected and uninfected erythrocytes. Clinicopathological correlation showed that sequestration and congestion were significantly associated with deeper levels of premortem coma and shorter time to death. Microvascular congestion and sequestration were highly correlated as microscopic findings but were independent predictors of a clinical diagnosis of CM. Increased microvascular congestion accompanies coma in CM, associated with parasite sequestration in the cerebral microvasculature. |
| | |
Authors:
|
Mark J Ponsford; Isabelle M Medana; Panote Prapansilp; Tran Tinh Hien; Sue J Lee; Arjen M Dondorp; Margaret M Esiri; Nicholas P J Day; Nicholas J White; Gareth D H Turner |
Related Documents
:
|
2178318 - Isolation of bovine eosinophils and characterization of their leukotriene formation. 7151978 - Uptake of fat by fluorescent granular perithelial cells in cerebral cortex after admini... 11605648 - Thermal behaviour of diclofenac sodium: decomposition and melting characteristics. 8209638 - View of the brain through a flow-coloured time window. 9867318 - Type iii and type iv endoleak: toward a complete definition of blood flow in the sac af... 17120638 - Bottom shear stress in unsteady sewer flow. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-12-29 |
Journal Detail:
|
Title: The Journal of infectious diseases Volume: - ISSN: 1537-6613 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2011-12-30 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0413675 Medline TA: J Infect Dis Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Nuffield Department of Clinical Laboratory Sciences. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Antiviral Activity of Coxsackievirus B3 3C Protease Inhibitor in Experimental Murine Myocarditis.
Next Document: Immune Response Following H1N1pdm09 Vaccination: Differences in Antibody Repertoire and Avidity in Y...