Document Detail

Sequential use of Prepidil and extra-amniotic saline infusion for the induction of labor in nulliparous women with very low Bishop scores.
MedLine Citation:
PMID:  11444789     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the efficacy of sequential use of Prepidil (prostaglandin E2 gel) and extra-amniotic saline infusion for the induction of labor in nulliparous women with very low Bishop scores. STUDY DESIGN: Nulliparous women with singleton gestations, intact membranes and a cervical Bishop score of < or = 2 who received Prepidil gel and extra-amniotic saline infusion sequentially for the induction of labor between July 1996 and July 1998 were studied. RESULTS: Thirty-one women met the inclusion criteria. Indications for induction included post-dates (six of 31), pre-eclampsia (ten of 31), diabetes (three of 31), oligohydramnios (three of 31), intrauterine growth restriction (two of 31) and non-reactive non-stress test (NST) (seven of 31). The average time from onset of induction to delivery was 38.1 +/- 13.5 h. Vaginal delivery was achieved in 80.6%. Women requiring > 2 doses of Prepidil had a higher risk of delivering abdominally (OR = 3.5). Three of seven (42.9%) women with labor induced for non-reactive NST but only three of 24 (12.5%) with labor induced for other indications had a Cesarean section delivery (p < 0.001). CONCLUSIONS: Nulliparous women with very unfavorable cervices can be counselled that they have an 80% chance of vaginal delivery using sequential Prepidil and extra-amniotic saline infusion as an induction method, with 90% delivering within the first 48 h.
M F Chammas; T M Nguyen; R A Vasavada; B S Nuwayhid; L C Castro
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  The Journal of maternal-fetal medicine     Volume:  10     ISSN:  1057-0802     ISO Abbreviation:  J Matern Fetal Med     Publication Date:  2001 Jun 
Date Detail:
Created Date:  2001-07-10     Completed Date:  2001-12-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9211288     Medline TA:  J Matern Fetal Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  193-6     Citation Subset:  IM    
Department of Obstetrics and Gynecology, College of Medicine, University of Illinois at Chicago, 60612, USA.
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MeSH Terms
Administration, Intravaginal
Amnion / drug effects*
Apgar Score
Cervical Ripening / drug effects
Cesarean Section
Dinoprostone / administration & dosage*,  therapeutic use*
Gestational Age
Infant, Newborn
Infusions, Parenteral*
Labor Onset / drug effects
Labor, Induced*
Oxytocics / administration & dosage*,  therapeutic use*
Pregnancy Outcome
Sodium Chloride / administration & dosage*,  therapeutic use*
Time Factors
Reg. No./Substance:
0/Oxytocics; 363-24-6/Dinoprostone; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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