Document Detail

Sequential transformation of t(8;13)-related disease: a case report.
MedLine Citation:
PMID:  11919389     Owner:  NLM     Status:  MEDLINE    
We report a case of an atypical myeloproliferative disorder with t(8;13) that presented as B-lineage acute lymphoblastic leukaemia (B-ALL). Following induction chemotherapy, the disease manifested as chronic myeloproliferative state, which responded to hydroxyurea. Terminally, the disease transformed into acute myeloid leukaemia (AML) with additional chromosomal abnormalities including monosomy 7. To our knowledge, this is the first case of this rare atypical myeloproliferative disorder with t(8;13) that presented as B-ALL and terminally transformed to AML with additional chromosomal abnormalities.
S Roy; J Szer; L J Campbell; S Juneja
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Acta haematologica     Volume:  107     ISSN:  0001-5792     ISO Abbreviation:  Acta Haematol.     Publication Date:  2002  
Date Detail:
Created Date:  2002-03-28     Completed Date:  2002-06-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0141053     Medline TA:  Acta Haematol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  95-7     Citation Subset:  IM    
Copyright Information:
Copyright 2002 S. Karger AG, Basel
Royal Melbourne Hospital, Melbourne, Australia.
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MeSH Terms
Acute Disease
Burkitt Lymphoma / diagnosis,  genetics*,  pathology
Cell Lineage
Cell Transformation, Neoplastic / pathology*
Chromosomes, Human, Pair 13*
Chromosomes, Human, Pair 8*
Diagnosis, Differential
Leukemia, Myeloid / diagnosis,  genetics,  pathology
Myeloproliferative Disorders / diagnosis,  genetics*,  pathology
Translocation, Genetic*

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