Document Detail

Sequential release of histamine and 5-hydroxytryptamine during pinnal anaphylaxis in the mouse.
MedLine Citation:
PMID:  65336     Owner:  NLM     Status:  MEDLINE    
Histamine and 5-HT have been demonstrated to be involved in pinnal anaphylaxis in mice. Each predominates at different stages during the 30-min development of the reaction. The main mediator of the early stage of the reaction (0-10 min) is histamine, that of the middle stage (10-20 min) is 5-HT, and that of the final 20- to 30-min stage is, again, histamine. The source and mechanism of release of the 5-HT and the late histamine are, as yet, unknown but under investigation.
P Miller; M K Church
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International archives of allergy and applied immunology     Volume:  52     ISSN:  0020-5915     ISO Abbreviation:  Int. Arch. Allergy Appl. Immunol.     Publication Date:  1976  
Date Detail:
Created Date:  1977-04-25     Completed Date:  1977-04-25     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  0404561     Medline TA:  Int Arch Allergy Appl Immunol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  53-8     Citation Subset:  IM    
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MeSH Terms
Anaphylaxis / metabolism*
Histamine Release*
Methysergide / pharmacology
Pyrilamine / pharmacology
Serotonin / secretion*
Skin / immunology
Time Factors
Reg. No./Substance:
361-37-5/Methysergide; 50-67-9/Serotonin; 91-84-9/Pyrilamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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