Document Detail

Sequential production of leukaemia inhibitory factor by blood cell culture in patients with ARDS.
MedLine Citation:
PMID:  9609417     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Leukaemia inhibitory factor (LIF) is a polyfunctional cytokine integrated in cytokine networks and its concentration has been shown to be elevated in bronchoalveolar lavage fluid of patients with the acute respiratory distress syndrome (ARDS). The aim of our study was to evaluate the production of LIF by culturing blood cells from patients with ARDS. PATIENTS: 8 patients with ARDS, 8 patients with pneumonia and 5 healthy subjects. MEASUREMENTS AND RESULTS: The blood samples were taken on day 1 after onset of ARDS. LIF was measured, in the cell-free supernatant, with an enzyme-linked immunosorbent assay after 24 h, 48 h and 72 h of blood cell culture. LIF was detectable in some patients in the ARDS group: at i) at 24 h and 48 h: in 2 patients ii) at 72 h in 4/5 patients (140 +/- 231 pg/ml). Only in the 4 patients in whom LIF was measured at 72 h was ARDS associated with the multiple organ dysfunction syndrome. Furthermore, among the 5 patients with ARDS who subsequently died, 4 had a detectable LIF. CONCLUSIONS: We have observed that LIF was produced only in ARDS, but not in all patients. The production of LIF seems to be a good indicator of the severity of ARDS. These preliminary results must be confirmed by a larger study.
D Gruson; G Hilbert; M Juzan; J L Taupin; V Coulon; J F Moreau; N Gualde; G Gbikpi-Benissan
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Intensive care medicine     Volume:  24     ISSN:  0342-4642     ISO Abbreviation:  Intensive Care Med     Publication Date:  1998 Apr 
Date Detail:
Created Date:  1998-07-16     Completed Date:  1998-07-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7704851     Medline TA:  Intensive Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  366-8     Citation Subset:  IM    
Réanimation médicale B, Hôpital Pellegrin, Bordeaux, France.
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MeSH Terms
Case-Control Studies
Cell Culture Techniques
Enzyme-Linked Immunosorbent Assay
Growth Inhibitors / blood*
Leukemia Inhibitory Factor
Lymphokines / blood*
Middle Aged
Multiple Organ Failure / etiology
Pneumonia / blood,  immunology
Prospective Studies
Respiratory Distress Syndrome, Adult / blood*,  complications,  immunology*,  mortality
Time Factors
Reg. No./Substance:
0/Growth Inhibitors; 0/Interleukin-6; 0/LIF protein, human; 0/Leukemia Inhibitory Factor; 0/Lymphokines

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