| Sequential production of leukaemia inhibitory factor by blood cell culture in patients with ARDS. | |
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MedLine Citation:
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PMID: 9609417 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Leukaemia inhibitory factor (LIF) is a polyfunctional cytokine integrated in cytokine networks and its concentration has been shown to be elevated in bronchoalveolar lavage fluid of patients with the acute respiratory distress syndrome (ARDS). The aim of our study was to evaluate the production of LIF by culturing blood cells from patients with ARDS. PATIENTS: 8 patients with ARDS, 8 patients with pneumonia and 5 healthy subjects. MEASUREMENTS AND RESULTS: The blood samples were taken on day 1 after onset of ARDS. LIF was measured, in the cell-free supernatant, with an enzyme-linked immunosorbent assay after 24 h, 48 h and 72 h of blood cell culture. LIF was detectable in some patients in the ARDS group: at i) at 24 h and 48 h: in 2 patients ii) at 72 h in 4/5 patients (140 +/- 231 pg/ml). Only in the 4 patients in whom LIF was measured at 72 h was ARDS associated with the multiple organ dysfunction syndrome. Furthermore, among the 5 patients with ARDS who subsequently died, 4 had a detectable LIF. CONCLUSIONS: We have observed that LIF was produced only in ARDS, but not in all patients. The production of LIF seems to be a good indicator of the severity of ARDS. These preliminary results must be confirmed by a larger study. |
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Authors:
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D Gruson; G Hilbert; M Juzan; J L Taupin; V Coulon; J F Moreau; N Gualde; G Gbikpi-Benissan |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Intensive care medicine Volume: 24 ISSN: 0342-4642 ISO Abbreviation: Intensive Care Med Publication Date: 1998 Apr |
Date Detail:
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Created Date: 1998-07-16 Completed Date: 1998-07-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7704851 Medline TA: Intensive Care Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 366-8 Citation Subset: IM |
Affiliation:
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Réanimation médicale B, Hôpital Pellegrin, Bordeaux, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Case-Control Studies Cell Culture Techniques Enzyme-Linked Immunosorbent Assay Female Growth Inhibitors / blood* Humans Interleukin-6* Leukemia Inhibitory Factor Lymphokines / blood* Male Middle Aged Multiple Organ Failure / etiology Pneumonia / blood, immunology Prospective Studies Respiratory Distress Syndrome, Adult / blood*, complications, immunology*, mortality Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Growth Inhibitors; 0/Interleukin-6; 0/LIF protein, human; 0/Leukemia Inhibitory Factor; 0/Lymphokines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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