Document Detail

Sequential perioperative lactate determination. Physiological and clinical implications.
MedLine Citation:
PMID:  7060384     Owner:  NLM     Status:  MEDLINE    
Sequential arterial blood lactate concentrations were determined pre-, intra-, and postoperatively in 12 high risk surgical patients. These levels were correlated with simultaneous measurements of arterial blood pressure, cardiac index (CI), and oxygen consumption (VO2). There was a marked increase in lactate values intraoperatively. This increase did not correspond to decreases in either mean arterial pressure (MAP) or CI, but did appear to correlate with decreased intraoperative VO2. Postoperatively, lactate levels remained elevated, and this elevation appeared to correlate with an estimation of intraoperative oxygen deficit. CI and VO2 were increased postoperatively; the data support the hypothesis that these postoperative increases in CI and VO2 represent physiological compensations for intraoperative oxygen deficits. Clinically, determinations of lactate values may prove useful in titrating postoperative therapy to support needed physiological compensations.
K Waxman; L S Nolan; W C Shoemaker
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Critical care medicine     Volume:  10     ISSN:  0090-3493     ISO Abbreviation:  Crit. Care Med.     Publication Date:  1982 Feb 
Date Detail:
Created Date:  1982-05-21     Completed Date:  1982-05-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0355501     Medline TA:  Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  96-9     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Pressure
Cardiac Output
Intraoperative Period
Lactates / blood*
Middle Aged
Oxygen Consumption*
Postoperative Care
Postoperative Period
Reg. No./Substance:

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