Document Detail


Sequential low-dose step-up and step-down protocols with recombinant follicle-stimulating hormone in polycystic ovary syndrome: prospective comparison with step-down protocol.
MedLine Citation:
PMID:  22729136     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
PURPOSE: To assess the differences in follicular development comparing two sequential low-dose step-up and step-down protocols (A: 37.5 IU/day, B: 75 IU/day) with a step-down protocol (C: 150 IU/day) using recombinant human follicle stimulating hormone (rFSH) in women with polycystic ovarian syndrome (PCOS). METHODS: In this prospective observational comparative study, 60 PCOS women were treated with one of the three protocols for only one cycle. RESULT(S): Monofollicular development was similar among the three protocols but the total number of follicles >10 mm in diameter was significantly lower in group A (1 ± 0.94 vs 6.3 ± 2.45 vs 8.6 ± 4.45; P = 0.001 A vs B; P < 0.001 A vs C). Cycle cancellation rate was higher in protocol A and in protocol C because of no ovarian response and excessive multifollicular development, respectively. The total amount of rFSH for complete cycle was significantly lower in protocol A (P = 0.02 A vs B; P = 0.007 A vs C). No mild or severe hyperstimulation syndrome (OHSS) was observed. CONCLUSION(S): A and B protocols seem to be a more effective approach than the step-down protocol. In both groups, the pregnancy rate for started cycle was the same. Protocol A has allowed the development of a lower number of small follicles, single pregnancies, but an excessive number of cancelled cycles occurred. In protocol B no cycle cancellation occurred, though the total rFSH dosage was significantly higher than the protocol A and two twin pregnancies were observed.
Authors:
Luisa Casadei; Francesco Puca; Emanuela Emidi; Claudia Manicuti; Alessandra Madrigale; Emilio Piccione
Related Documents :
2976616 - Ovarian abscess following cesarean section. a case report and review of literature.
6850046 - Exposure to diethylstilbestrol during pregnancy permanently alters the ovary and oviduct.
16410336 - Follow-up study of two sisters with type a syndrome of severe insulin resistance gives ...
23859416 - Factors associated with cord blood ige levels.
18495356 - Preliminary evidence for a modulation of fetal dopaminergic development by maternal imm...
14619646 - Converting an ivf cycle to iui in low responders with at least 2 follicles.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-24
Journal Detail:
Title:  Archives of gynecology and obstetrics     Volume:  -     ISSN:  1432-0711     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8710213     Medline TA:  Arch Gynecol Obstet     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Academic Department of Biomedicine & Prevention, Section of Gynecology and Obstetrics, Tor Vergata University, Rome, Italy, Casadei@med.uniroma2.it.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Development and content validity of the Therapy Behavior Scale.
Next Document:  Influence of body mass index on clinicopathologic features, surgical morbidity and outcome in patien...