Document Detail

Sequential histological study of lepromin reaction.
MedLine Citation:
PMID:  6686971     Owner:  NLM     Status:  MEDLINE    
Skin testing with Dharmendra antigen was performed on 55 patients with TT, BT, BL, and LL types of leprosy and the reaction measured at different intervals from 24 hr to 28 days. At various time intervals, a biopsy specimen was taken from the reaction site. In TT and BT cases, the erythema was maximum at 48 hr; while the induration was maximum at 21 days. The sequence of the histological changes was built up on the observations made from different cases at varying intervals. The quantum of cellular exudate was high in TT and BT cases as compared to BL and LL cases. The cellular distribution showed loose scattering of cells in the LL and BL types and attempts to form tight clusters in the TT and BT cases. Neutrophils were predominant during the first 48 hr, particularly in the LL, BL, and BT types. By 72 hr the cells were mainly lymphocytic. A tendency for the lymphocytes to cluster around nerve twigs was seen in the TT and BT cases. In the early reaction the quantum of exudate correlated both with erythema and induration; while in the late reaction, it correlated with induration only. The intensity of the early lepromin reaction was more in BT than in TT leprosy, while the induration in the late reaction was more in TT than in BT types. The significance of these findings is discussed.
K V Desikan; A Mukherjee; G Ramu; V D Tiwari
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association     Volume:  51     ISSN:  0148-916X     ISO Abbreviation:  Int. J. Lepr. Other Mycobact. Dis.     Publication Date:  1983 Dec 
Date Detail:
Created Date:  1984-05-02     Completed Date:  1984-05-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8505819     Medline TA:  Int J Lepr Other Mycobact Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  473-80     Citation Subset:  IM    
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MeSH Terms
Edema / pathology
Erythema / pathology
Exudates and Transudates / analysis,  cytology
Lepromin / immunology*
Leprosy / classification,  immunology*,  pathology
Lymphocytes / pathology
Middle Aged
Neutrophils / pathology
Skin / innervation,  pathology
Time Factors
Reg. No./Substance:

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