| Sequential expression in the nervous system of c-myb and VIP genes, located in human chromosomal region 6q24. | |
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MedLine Citation:
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PMID: 2842874 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Vasoactive intestinal peptide (VIP) is a major neuropeptide involved in multiple functions such as vasodilation, smooth-muscle relaxation, sweat secretion, gastrointestinal peristalsis, pancreatic function, and brain activity. In view of the multiple roles associated with VIP, it is important to understand its gene regulation. We have recently isolated the human VIP gene and determined its structure. By in situ hybridization techniques we have now localized this gene to the long arm of chromosome 6, 6q24, a chromosomal region that has been shown previously to contain the coding sequences for the nuclear protooncogene c-myb. Genes found in close proximity to each other on the chromosome are often functionally related and, as VIP is primarily expressed in the nervous system, we investigated the possible correlation of c-myb to VIP in neuronal tissue. A sharp peak of c-myb mRNA was observed in the hippocampus of 3-day-old rats, preceding the peak of VIP mRNA that occurs in this brain area at 8 days of age. Thus, the protooncogene c-myb may be associated with events in brain development occurring prior to the appearance of elevated concentrations of VIP. |
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Authors:
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I Gozes; H Nakai; M Byers; R Avidor; Y Weinstein; Y Shani; T B Shows |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Somatic cell and molecular genetics Volume: 13 ISSN: 0740-7750 ISO Abbreviation: Somat. Cell Mol. Genet. Publication Date: 1987 Jul |
Date Detail:
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Created Date: 1988-10-13 Completed Date: 1988-10-13 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8403568 Medline TA: Somat Cell Mol Genet Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 305-13 Citation Subset: IM |
Affiliation:
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Department of Hormone Research, Weizmann Institute of Science, Rehovot, Israel. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / growth & development* Chromosome Mapping* Chromosomes, Human, Pair 6* DNA Restriction Enzymes Exons Gene Expression Regulation Genetic Vectors Humans Karyotyping Nucleic Acid Hybridization Plasmids Proto-Oncogenes* RNA, Messenger / biosynthesis Rats Vasoactive Intestinal Peptide / genetics* |
| Grant Support | |
ID/Acronym/Agency:
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GM 20454/GM/NIGMS NIH HHS; HD05196/HD/NICHD NIH HHS; NS 19860/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/RNA, Messenger; 37221-79-7/Vasoactive Intestinal Peptide; EC 3.1.21.-/DNA Restriction Enzymes |
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