Document Detail


Sequential enzymatic epoxidation involved in polyether lasalocid biosynthesis.
MedLine Citation:
PMID:  22506807     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Enantioselective epoxidation followed by regioselective epoxide opening reaction are the key processes in construction of the polyether skeleton. Recent genetic analysis of ionophore polyether biosynthetic gene clusters suggested that flavin-containing monooxygenases (FMOs) could be involved in the oxidation steps. In vivo and in vitro analyses of Lsd18, an FMO involved in the biosynthesis of polyether lasalocid, using simple olefin or truncated diene of a putative substrate as substrate mimics demonstrated that enantioselective epoxidation affords natural type mono- or bis-epoxide in a stepwise manner. These findings allow us to figure out enzy-matic polyether construction in lasalocid biosynthesis.
Authors:
Atsushi Minami; Mayu Shimaya; Gaku Suzuki; Akira Migita; Sandip S Shinde; Kyohei Sato; Kenji Watanabe; Tomohiro Tamura; Hiroki Oguri; Hideaki Oikawa
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-17
Journal Detail:
Title:  Journal of the American Chemical Society     Volume:  -     ISSN:  1520-5126     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7503056     Medline TA:  J Am Chem Soc     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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