| Sequential dynamic gadolinium magnetic resonance perfusion-weighted imaging: effects on transit time and cerebral blood volume measurements. | |
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MedLine Citation:
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PMID: 17135012 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To evaluate if two gadolinium perfusion studies can be performed during the same table occupancy without degradation of the derived data in the second study. MATERIAL AND METHODS: Magnetic resonance (MR) perfusion studies of the whole brain were performed on 12 patients during the administration of two gadolinium boluses separated by 8 min. In six patients, gadolinium was given as two 20-ml administrations of standard 0.5 M chelate (Magnevist), whilst the other six patients received two 10-ml administrations of 1.0 M chelate (Gadovist). RESULTS: There were no significant differences in subjective quality between the time-intensity curves of the first and second perfusion studies using either the 0.5 M or 1.0 M gadolinium chelate. The objective measurements in quality of the time-intensity curves (maximum signal change and full width at half maximum) changed by less than 5% of the original values on the second perfusion study. The first-moment mean transit times did not change significantly on the sequential studies. The regional cerebral blood volume tended to increase on the second study (by 15% on average), but this did not reach statistical significance. CONCLUSION: The results from two sequential dynamic gadolinium-based perfusion studies can be compared in a meaningful manner using the technique described. |
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Authors:
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P D Griffiths; H Pandya; I D Wilkinson; N Hoggard |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta radiologica (Stockholm, Sweden : 1987) Volume: 47 ISSN: 0284-1851 ISO Abbreviation: Acta Radiol Publication Date: 2006 Dec |
Date Detail:
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Created Date: 2006-11-30 Completed Date: 2007-02-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8706123 Medline TA: Acta Radiol Country: Sweden |
Other Details:
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Languages: eng Pagination: 1079-84 Citation Subset: IM |
Affiliation:
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Unit of Academic Radiology, Royal Hallamshire Hospital, Sheffield, United Kingdom. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Blood Volume Determination / methods* Cerebrovascular Circulation* Contrast Media / administration & dosage, pharmacokinetics* Female Gadolinium DTPA / administration & dosage, pharmacokinetics* Humans Magnetic Resonance Imaging / methods* Male Middle Aged Organometallic Compounds / administration & dosage, pharmacokinetics* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/Organometallic Compounds; 138071-82-6/gadobutrol; 80529-93-7/Gadolinium DTPA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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