Document Detail


Sequential combination of two intravenous thrombolytics (recombinant tissue plasminogen activator/tenecteplase) in a patient with stroke and cardioembolic basilar artery occlusion.
MedLine Citation:
PMID:  19110148     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Stroke caused by acute occlusion of basilar artery (AOBA) produces high risk of death. In eligible patients, thrombolysis significantly reduces mortality and disability rate. In most hospitals, thrombolysis is limited to intravenous (IV) route of recombinant tissue plasminogen activator, without any therapeutic alternative in cases of treatment failure. We report a case of cardioembolic AOBA, not responsive to a conventional regimen of IV recombinant tissue plasminogen activator. A sequential combination of IV tenecteplase (0.4 mg/kg) led to a complete recanalization of basilar artery, with a very good clinical outcome. The potential for a combination of two successive IV regimens should be evaluated in AOBA.
Authors:
Didier Smadja; Stéphane Olindo; Martine Saint-Vil; Nicolas Chausson
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association     Volume:  18     ISSN:  1532-8511     ISO Abbreviation:  J Stroke Cerebrovasc Dis     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2008-12-26     Completed Date:  2009-02-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9111633     Medline TA:  J Stroke Cerebrovasc Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  68-71     Citation Subset:  IM    
Affiliation:
Department of Neurology, University Hospital of Fort-de-France, Martinique, the French West Indies. didier.smadja@chu-fortdefrance.fr
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MeSH Terms
Descriptor/Qualifier:
Aged
Diffusion Magnetic Resonance Imaging
Drug Therapy, Combination
Embolism / complications*,  drug therapy,  pathology
Fibrinolytic Agents / administration & dosage*
Heart Diseases / complications*,  drug therapy,  pathology
Humans
Infusions, Intravenous
Magnetic Resonance Angiography
Male
Recombinant Proteins / administration & dosage
Stroke / drug therapy*,  etiology,  pathology
Thrombolytic Therapy*
Tissue Plasminogen Activator / administration & dosage*
Treatment Outcome
Vertebrobasilar Insufficiency / drug therapy*,  etiology,  pathology
Chemical
Reg. No./Substance:
0/Fibrinolytic Agents; 0/Recombinant Proteins; 0/tenecteplase; EC 3.4.21.68/Tissue Plasminogen Activator

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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