| Sequential combination of two intravenous thrombolytics (recombinant tissue plasminogen activator/tenecteplase) in a patient with stroke and cardioembolic basilar artery occlusion. | |
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MedLine Citation:
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PMID: 19110148 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Stroke caused by acute occlusion of basilar artery (AOBA) produces high risk of death. In eligible patients, thrombolysis significantly reduces mortality and disability rate. In most hospitals, thrombolysis is limited to intravenous (IV) route of recombinant tissue plasminogen activator, without any therapeutic alternative in cases of treatment failure. We report a case of cardioembolic AOBA, not responsive to a conventional regimen of IV recombinant tissue plasminogen activator. A sequential combination of IV tenecteplase (0.4 mg/kg) led to a complete recanalization of basilar artery, with a very good clinical outcome. The potential for a combination of two successive IV regimens should be evaluated in AOBA. |
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Authors:
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Didier Smadja; Stéphane Olindo; Martine Saint-Vil; Nicolas Chausson |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association Volume: 18 ISSN: 1532-8511 ISO Abbreviation: J Stroke Cerebrovasc Dis Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2008-12-26 Completed Date: 2009-02-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9111633 Medline TA: J Stroke Cerebrovasc Dis Country: United States |
Other Details:
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Languages: eng Pagination: 68-71 Citation Subset: IM |
Affiliation:
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Department of Neurology, University Hospital of Fort-de-France, Martinique, the French West Indies. didier.smadja@chu-fortdefrance.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Diffusion Magnetic Resonance Imaging Drug Therapy, Combination Embolism / complications*, drug therapy, pathology Fibrinolytic Agents / administration & dosage* Heart Diseases / complications*, drug therapy, pathology Humans Infusions, Intravenous Magnetic Resonance Angiography Male Recombinant Proteins / administration & dosage Stroke / drug therapy*, etiology, pathology Thrombolytic Therapy* Tissue Plasminogen Activator / administration & dosage* Treatment Outcome Vertebrobasilar Insufficiency / drug therapy*, etiology, pathology |
| Chemical | |
Reg. No./Substance:
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0/Fibrinolytic Agents; 0/Recombinant Proteins; 0/tenecteplase; EC 3.4.21.68/Tissue Plasminogen Activator |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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