Document Detail

Sequential clinical and immunologic abnormalities in hemophiliacs.
MedLine Citation:
PMID:  3919666     Owner:  NLM     Status:  MEDLINE    
We examined 35 patients with hemophilia to determine if there was an association between impaired cell-mediated immunity and the amount of factor concentrate use. There was a significant negative relationship between the logarithm of the helper-suppressor ratio and the logarithm of concentrate use determined over the previous one year, five years, and total lifetime. Similarly, the presence of splenomegaly was significantly associated with the logarithm of concentrate use for each time interval. Hypergammaglobulinemia, anergy, and lymphadenopathy were present in a high proportion of patients. Repeated study of 30 of these patients at eight to 14 months showed no significant changes in their T-cell subsets. At follow-up, 16 patients had lymphadenopathy with or without splenomegaly and four had splenomegaly alone. No significant associations between concentrate use during the study period and changes in T-cell subsets or clinical condition were found.
J M Goldsmith; S B Kalish; D Green; J S Chmiel; C B Wallemark; J P Phair
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives of internal medicine     Volume:  145     ISSN:  0003-9926     ISO Abbreviation:  Arch. Intern. Med.     Publication Date:  1985 Mar 
Date Detail:
Created Date:  1985-04-09     Completed Date:  1985-04-09     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372440     Medline TA:  Arch Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  431-4     Citation Subset:  AIM; IM    
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MeSH Terms
Factor VIII / therapeutic use
Follow-Up Studies
Hemophilia A / immunology*,  therapy
Hemophilia B / immunology,  therapy
Hypergammaglobulinemia / immunology
Immunity, Cellular
Leukocyte Count
Lymphatic Diseases / immunology
Middle Aged
Splenomegaly / immunology
T-Lymphocytes / classification
Grant Support
Reg. No./Substance:
9001-27-8/Factor VIII

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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