| Sequential chemoradiotherapy versus radiotherapy in the management of locally advanced non-small-cell lung cancer. | |
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MedLine Citation:
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PMID: 12772814 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This prospective randomized trial compared neoadjuvant chemotherapy followed by local-regional radiotherapy (study group) with radiotherapy alone (control group) in 506 patients with locally advanced non-small-cell lung cancer. The study group received three cycles of cisplatin, ifosfamide with Mesna, and mitomycin C at 21-day intervals. Radiotherapy was delivered up to a dose of 60 Gy. Evaluable patients numbered 460. In the study group, 228 patients were assessed for tumor response after chemotherapy: 13 (5.7%) had a complete response; 103 (43.2%), a partial response; 48 (21%) showed no change; and 74 patients (31.1%) had progressive disease. These patients then received chest irradiation, which was well tolerated. On completion of radiotherapy, 16.2% of the study group and 6% of the control group had a complete response. No change was seen in 10.1% of study patients and 15.5% of control patients. Respective rates for disease progression were 27.6% and 42.3%. Actuarial 2-year survival was 20% in the study group and 7.4% in the control group. |
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Authors:
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Shantanu Sharma; Rajiv Sharma; Kumar T Bhowmik |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Advances in therapy Volume: 20 ISSN: 0741-238X ISO Abbreviation: Adv Ther Publication Date: 2003 Jan-Feb |
Date Detail:
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Created Date: 2003-05-29 Completed Date: 2003-06-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8611864 Medline TA: Adv Ther Country: United States |
Other Details:
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Languages: eng Pagination: 14-9 Citation Subset: T |
Affiliation:
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Department of Radiotherapy, Vardhman Mahavir Medical College, Safdarjang Hospital, New Delhi, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Antineoplastic Combined Chemotherapy Protocols / therapeutic use* Biopsy, Needle Brachytherapy / methods* Carcinoma, Non-Small-Cell Lung / drug therapy*, mortality, pathology, radiotherapy* Cisplatin / therapeutic use Combined Modality Therapy Female Humans Ifosfamide / therapeutic use Lung Neoplasms / drug therapy*, mortality, pathology, radiotherapy* Male Middle Aged Mitomycin / therapeutic use Neoadjuvant Therapy Neoplasm Staging Prognosis Prospective Studies Radiotherapy Dosage Risk Assessment Sensitivity and Specificity Survival Analysis Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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15663-27-1/Cisplatin; 3778-73-2/Ifosfamide; 50-07-7/Mitomycin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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