| Sequential changes of serum aminotransferase levels in patients with severe acute respiratory syndrome. | |
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MedLine Citation:
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PMID: 15306699 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Severe acute respiratory syndrome (SARS) is a newly emerging infectious disease. To describe the hepatic injury caused by this disease, we report the sequential changes of serum transaminase in probable SARS patients during a hospital outbreak in southern Taiwan. From April to June, 2003, 52 probable SARS patients were hospitalized. Serial serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were retrospectively analyzed and hepatitis B surface antigen (HBsAg) was also evaluated to correlate with the progression of this disease. Fifty-three percent of the patients had abnormal liver function during hospitalization. More than 70% of abnormal transaminase levels were mildly elevated. Most elevated levels were noted during the second week after onset of fever. Neither transaminase elevation nor HBsAg was related to the prognosis of SARS, and only advanced age was an independent predictor of poor outcome. Our study suggested that coronavirus causing SARS might induce liver damage. |
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Authors:
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Keng-Liang Wu; Sheng-Nan Lu; Chi-Sin Changchien; King-Wah Chiu; Chung-Huang Kuo; Seng-Kee Chuah; Jien-Wei Liu; Meng-Chih Lin; Hock-Liew Eng; Shun-Sheng Chen; Chuan-Mo Lee; Chao-Long Chen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The American journal of tropical medicine and hygiene Volume: 71 ISSN: 0002-9637 ISO Abbreviation: Am. J. Trop. Med. Hyg. Publication Date: 2004 Aug |
Date Detail:
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Created Date: 2004-08-12 Completed Date: 2004-09-17 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370507 Medline TA: Am J Trop Med Hyg Country: United States |
Other Details:
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Languages: eng Pagination: 125-8 Citation Subset: AIM; IM |
Affiliation:
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Division of Hepato-Gastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan, Republic of China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Alanine Transaminase / blood* Aspartate Aminotransferases / blood* Disease Progression Female Hepatitis B Surface Antigens / blood Humans Male Middle Aged Retrospective Studies SARS Virus Severe Acute Respiratory Syndrome / epidemiology, physiopathology*, virology Taiwan Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Hepatitis B Surface Antigens; EC 2.6.1.1/Aspartate Aminotransferases; EC 2.6.1.2/Alanine Transaminase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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