| Sequential changes in serum levels of individual bile acids in patients with chronic cholestatic liver disease. | |
| | |
MedLine Citation:
|
PMID: 8742915 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In order to determine the value of serum bile acids in predicting the course of chronic cholestatic liver diseases, we measured individual serum bile acids serially, using high-performance liquid chromatography, over a 4 year observation period in 12 patients with primary biliary cirrhosis and six patients with primary sclerosing cholangitis. The changes in individual serum bile acids and the ratios thereof, conventional liver tests and Child-Turcotte and Mayo scores were compared between survivors (n = 10) and patients who underwent liver transplantation for (n = 3) or died of the liver disease (n = 5). Patients with a serum total chenodeoxycholic acid concentration at study entry that exceded 15 mumol/L were 10 times more likely to die or need a liver transplant in the following 4 years than those with chenodeoxycholic acid levels < 15 mumol/L (P < 0.05). None of the other biochemical parameters or clinicopathological scores could similarly discriminate between the two groups at entry. Time-dependent analyses for the cholic acid/chenodeoxycholic acid ratio, serum total bilirubin and albumin concentrations and Child-Turcotte and Mayo scores were able to differentiate between primary sclerosing cholangitis patients who died or were transplanted and those who were not, whereas age of the patients and other parameters did not. The taurocholic acid/taurochenodeoxycholic acid ratio fell during progression of primary biliary cirrhosis but rose in temporal relationship with primary sclerosing cholangitis. This differential pattern of change was unique compared with other clinical and laboratory indices. In conclusion, serum chenodeoxycholic acid levels and the cholic acid/chenodeoxycholic acid ratio in both diseases were independent indices that allowed for the prediction of survival or the need for liver transplantation. These indices are worthy of further examination in a larger group of patients as prognostic criteria for chronic cholestatic liver disease and in the assessment of the efficacy of therapeutic interventions, including liver transplantations. |
| | |
Authors:
|
S A Azer; S A Coverdale; K Byth; G C Farrell; N H Stacey |
Related Documents
:
|
2551765 - Ursodeoxycholic acid in primary biliary cirrhosis: results of a controlled double-blind... 8900905 - Feedback regulation of bile acid synthesis measured by stable isotope kinetics in humans. 19017045 - Topical 5-aminolevulinic acid photodynamic therapy for recalcitrant facial flat wart in... 3440935 - Effect of tablet solubility and hygroscopicity on disintegrant efficiency in direct com... 2999315 - Rapid inactivation of rotaviruses by exposure to acid buffer or acidic gastric juice. 2914385 - Homogentisic acid determined in biological fluids by hplc. |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of gastroenterology and hepatology Volume: 11 ISSN: 0815-9319 ISO Abbreviation: J. Gastroenterol. Hepatol. Publication Date: 1996 Mar |
Date Detail:
|
Created Date: 1996-09-25 Completed Date: 1996-09-25 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8607909 Medline TA: J Gastroenterol Hepatol Country: AUSTRALIA |
Other Details:
|
Languages: eng Pagination: 208-15 Citation Subset: IM |
Affiliation:
|
Toxicology Unit, National Institute of Occupational Health and Safety, Sydney, Australia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Bile Acids and Salts / blood* Chenodeoxycholic Acid / blood Cholangitis, Sclerosing / blood Cholestasis / complications* Cholic Acid Cholic Acids / blood Chromatography, High Pressure Liquid Chronic Disease Female Humans Liver Cirrhosis, Biliary / blood Liver Diseases / blood*, etiology, mortality Male Middle Aged Predictive Value of Tests Prognosis Survival Rate |
| Chemical | |
Reg. No./Substance:
|
0/Bile Acids and Salts; 0/Cholic Acids; 474-25-9/Chenodeoxycholic Acid; 81-25-4/Cholic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Distribution of the different subtypes of hepatitis C virus in Japan and the effects of interferon: ...
Next Document: Vasopressin plus oxygen vs vasopressin alone in cirrhotic patients with portal-hypertensive gastropa...