Document Detail


Sequential changes in antiangiogenic factors in early pregnancy and risk of developing preeclampsia.
MedLine Citation:
PMID:  17515455     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Concentrations of soluble fms-like tyrosine kinase 1 (sFlt1) and soluble endoglin (sEng) increase in maternal blood with the approach of clinical preeclampsia. Although alterations in these circulating antiangiogenic factors herald the signs and symptoms of preeclampsia, in vitro studies suggest they may also play a role in regulating early placental cytotrophoblast functions. Early pregnancy changes in sFlt1 and sEng may thus identify women destined to develop preeclampsia. We performed a nested case-control study of 39 women who developed preeclampsia and 147 contemporaneous normotensive controls each with serum collected in the first (11 to 13 weeks of gestation) and second (17 to 20 weeks) trimesters. Whereas levels of sFlt1 and sEng at 11 to 13 weeks were similar between cases and controls (sFlt1: 3.5+/-0.3 ng/mL versus 3.0+/-0.1, P=0.14; sEng 6.9+/-0.3 ng/mL versus 6.6+/-0.2, P=0.37, respectively), at 17 to 20 weeks both were elevated in the women destined to develop preeclampsia (sFlt1: 4.1+/-0.5 ng/mL versus 3.1+/-0.1, P<0.05; sEng, 6.4+/-0.4 ng/mL versus 5.2+/-0.1, P<0.01). Women who developed preterm (<37 weeks) preeclampsia demonstrated even greater sequential changes: difference [delta{d}] between second and first trimester levels: dsFlt1, 0.63+/-0.91 ng/mL in preterm PE versus 0.05+/-0.15 in controls; dsEng, 0.73+/-0.77 ng/mL versus -1.32+/-0.18, P<0.01. Similar findings were noted in a cross-sectional analysis of specimens collected from the Calcium for Preeclampsia Prevention Study. In conclusion, sequential changes in antiangiogenic factors during early pregnancy may be useful for predicting preterm preeclampsia.
Authors:
Sarosh Rana; S Ananth Karumanchi; Richard J Levine; Shivalingappa Venkatesha; Jose Alejandro Rauh-Hain; Hector Tamez; Ravi Thadhani
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural     Date:  2007-05-21
Journal Detail:
Title:  Hypertension     Volume:  50     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-06-21     Completed Date:  2007-07-16     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  United States    
Other Details:
Languages:  eng     Pagination:  137-42     Citation Subset:  IM    
Affiliation:
Maternal Fetal Medicine Division, Women and Infants Hospital, Brown University, Providence, RI, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Algorithms
Angiogenesis Inhibitors / blood*
Antigens, CD / blood*
Case-Control Studies
Female
Humans
Pre-Eclampsia / etiology*
Predictive Value of Tests
Pregnancy
Pregnancy Trimester, First / blood*
Pregnancy Trimester, Second / blood*
Receptors, Cell Surface / blood*
Risk Factors
Vascular Endothelial Growth Factor Receptor-1 / blood*
Grant Support
ID/Acronym/Agency:
DK 065997/DK/NIDDK NIH HHS; DK 67397/DK/NIDDK NIH HHS; HD 39223/HD/NICHD NIH HHS; HL079594/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Angiogenesis Inhibitors; 0/Antigens, CD; 0/ENG protein, human; 0/Receptors, Cell Surface; EC 2.7.10.1/FLT1 protein, human; EC 2.7.10.1/Vascular Endothelial Growth Factor Receptor-1
Comments/Corrections
Comment In:
Hypertension. 2007 Jul;50(1):35-6   [PMID:  17515451 ]

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