Document Detail

Sequential changes in antiangiogenic factors in early pregnancy and risk of developing preeclampsia.
MedLine Citation:
PMID:  17515455     Owner:  NLM     Status:  MEDLINE    
Concentrations of soluble fms-like tyrosine kinase 1 (sFlt1) and soluble endoglin (sEng) increase in maternal blood with the approach of clinical preeclampsia. Although alterations in these circulating antiangiogenic factors herald the signs and symptoms of preeclampsia, in vitro studies suggest they may also play a role in regulating early placental cytotrophoblast functions. Early pregnancy changes in sFlt1 and sEng may thus identify women destined to develop preeclampsia. We performed a nested case-control study of 39 women who developed preeclampsia and 147 contemporaneous normotensive controls each with serum collected in the first (11 to 13 weeks of gestation) and second (17 to 20 weeks) trimesters. Whereas levels of sFlt1 and sEng at 11 to 13 weeks were similar between cases and controls (sFlt1: 3.5+/-0.3 ng/mL versus 3.0+/-0.1, P=0.14; sEng 6.9+/-0.3 ng/mL versus 6.6+/-0.2, P=0.37, respectively), at 17 to 20 weeks both were elevated in the women destined to develop preeclampsia (sFlt1: 4.1+/-0.5 ng/mL versus 3.1+/-0.1, P<0.05; sEng, 6.4+/-0.4 ng/mL versus 5.2+/-0.1, P<0.01). Women who developed preterm (<37 weeks) preeclampsia demonstrated even greater sequential changes: difference [delta{d}] between second and first trimester levels: dsFlt1, 0.63+/-0.91 ng/mL in preterm PE versus 0.05+/-0.15 in controls; dsEng, 0.73+/-0.77 ng/mL versus -1.32+/-0.18, P<0.01. Similar findings were noted in a cross-sectional analysis of specimens collected from the Calcium for Preeclampsia Prevention Study. In conclusion, sequential changes in antiangiogenic factors during early pregnancy may be useful for predicting preterm preeclampsia.
Sarosh Rana; S Ananth Karumanchi; Richard J Levine; Shivalingappa Venkatesha; Jose Alejandro Rauh-Hain; Hector Tamez; Ravi Thadhani
Related Documents :
22417755 - 'let men into the pregnancy'-men's perceptions about being tested for chlamydia and hiv...
11435745 - Factor analysis, including antihypertensive medication, of the outcome of pregnancy in ...
16567065 - The significance of under- or overweight during childhood as a risk factor for hyperten...
10329875 - Effects of pregnancy-induced hypertension on the essential fatty acid statuses of ecuad...
22563765 - Combined fetal fibronectin and cervical length and spontaneous preterm birth in asympto...
8652335 - Airway management for patients with a tracheal bronchus.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural     Date:  2007-05-21
Journal Detail:
Title:  Hypertension     Volume:  50     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-06-21     Completed Date:  2007-07-16     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  United States    
Other Details:
Languages:  eng     Pagination:  137-42     Citation Subset:  IM    
Maternal Fetal Medicine Division, Women and Infants Hospital, Brown University, Providence, RI, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Angiogenesis Inhibitors / blood*
Antigens, CD / blood*
Case-Control Studies
Pre-Eclampsia / etiology*
Predictive Value of Tests
Pregnancy Trimester, First / blood*
Pregnancy Trimester, Second / blood*
Receptors, Cell Surface / blood*
Risk Factors
Vascular Endothelial Growth Factor Receptor-1 / blood*
Grant Support
Reg. No./Substance:
0/Angiogenesis Inhibitors; 0/Antigens, CD; 0/ENG protein, human; 0/Receptors, Cell Surface; EC protein, human; EC Endothelial Growth Factor Receptor-1
Comment In:
Hypertension. 2007 Jul;50(1):35-6   [PMID:  17515451 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Inhibition of Rac1-derived reactive oxygen species in nucleus tractus solitarius decreases blood pre...
Next Document:  Regulation of renin secretion and expression in mice deficient in beta1- and beta2-adrenergic recept...