| Sequential change of virus markers in seroconverters with community-acquired infection of human T lymphotropic virus type I. | |
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MedLine Citation:
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PMID: 11237827 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Twenty-three human T lymphotropic virus type I (HTLV-I) seroconverters were identified among 1120 HTLV-I-seronegative adults followed up for 11 years in an area of Japan endemic for HTLV-I. The geometric mean titer of anti-HTLV-I was 1:453 in the first year after seroconversion; the titer of each subject did not change significantly during 2-10 years of follow-up. HTLV-I proviral DNA load was quantified in 15 seroconverters, and a broad range of levels was observed-from <10 to >1000 copies/10(5) peripheral blood mononuclear cells. However, there was no obvious change in HTLV-I proviral DNA load over several years within individual subjects. Therefore, both proviral DNA load and humoral response in adult HTLV-I seroconverters were shown to stabilize within a few years after initial infection. In addition, 1 subject tested positive for HTLV-I proviral DNA before antibody seroconversion, which suggests the existence of a window period in community-acquired infection. |
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Authors:
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A Okayama; S Stuver; M Iga; M Okamoto; N Mueller; M Matsuoka; K Yamaguchi; N Tachibana; H Tsubouchi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. Date: 2001-02-28 |
Journal Detail:
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Title: The Journal of infectious diseases Volume: 183 ISSN: 0022-1899 ISO Abbreviation: J. Infect. Dis. Publication Date: 2001 Apr |
Date Detail:
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Created Date: 2001-03-12 Completed Date: 2001-05-10 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0413675 Medline TA: J Infect Dis Country: United States |
Other Details:
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Languages: eng Pagination: 1031-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Internal Medicine II, Miyazaki Medical College, Kiyotake, Miyazaki 8891601, Japan. okayama@post1.miyazaki-med.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Antibodies, Viral / blood* Cohort Studies Community Health Services DNA, Viral / analysis Female HTLV-I Infections / blood, immunology*, virology Human T-lymphotropic virus 1 / genetics, immunology*, isolation & purification Humans Japan Male Mass Screening Middle Aged Proviruses / genetics, immunology*, isolation & purification Rural Population Viral Load |
| Grant Support | |
ID/Acronym/Agency:
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CA-38450/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Viral; 0/DNA, Viral |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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