Document Detail

Sequential change in action potential of rabbit epicardium during and following radiofrequency ablation.
MedLine Citation:
PMID:  10517659     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Although radiofrequency (RF) catheter ablation is used to treat certain cardiac arrhythmias, little is known regarding transient changes in cellular electrophysiology during and following RF delivery. Optical recordings of action potential (OAP) with voltage-sensitive dyes allow immunity from electrical noise during RF delivery. The purpose of this study was to clarify the possible synergistic effects of both the thermal and electrotonic components of RF ablation. METHODS AND RESULTS: In this study, OAPs were recorded on the epicardium of 16 isolated Langendorff-perfused rabbit hearts within or adjacent to lesions made by RF catheters. Hearts were perfused at room temperature with Tyrode's solution containing 2,3-butanedione monoxime and stained by the voltage-sensitive dye di-4-ANEPPS. OAPs were recorded before, during, and after RF pulses. Within the lesion, the action potential duration at 80% repolarization (APD80) of OAP decreased rapidly during the RF pulse, without recovery following the pulse. In the border zone surrounding the lesion, the RF energy resulted in a rapid decrease in APD80, which recovered promptly after the pulse (recovery time constant: 82 +/- 37 sec). APD80 was nonlinearly related to temperature during the RF ablation and responded faster to RF ablation than to purely thermal injury. CONCLUSION: The application of RF energy results in significant changes in myocardial cellular electrophysiologic properties. The RF energy has a combination of thermal and electrotonic effects on the myocardial tissue. The results of this in vitro study may illustrate the cellular basis for commonly observed phenomena in clinical practice.
C C Wu; R W Fasciano; H Calkins; L Tung
Related Documents :
1634689 - Transcoronary chemical ablation of ventricular tachycardia in chronic chagasic myocardi...
24640519 - The electrophysiological characteristics of isolated diastolic potentials in idiopathic...
12679939 - Experimental study on the feasibility and safety of radiofrequency ablation for seconda...
17452159 - Prospective assessment after pediatric cardiac ablation: fate of intracardiac structure...
21262079 - A comparison of cardiac post-conditioning and remote pre-conditioning in paediatric car...
12547999 - Experimental study on the effectiveness and safety of radiofrequency catheter ablation ...
21355069 - Initial salivary α-amylase activity predicts malignant ventricular arrhythmias and sho...
12499519 - A randomized comparison of direct stenting versus stenting with predilatation in native...
8417549 - Transthoracic defibrillation: effect of dual-pathway sequential pulse shocks and single...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of cardiovascular electrophysiology     Volume:  10     ISSN:  1045-3873     ISO Abbreviation:  J. Cardiovasc. Electrophysiol.     Publication Date:  1999 Sep 
Date Detail:
Created Date:  1999-11-09     Completed Date:  1999-11-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9010756     Medline TA:  J Cardiovasc Electrophysiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1252-61     Citation Subset:  IM    
Department of Internal Medicine, National Taiwan University Hospital, Taipei.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Action Potentials*
Arrhythmias, Cardiac / surgery
Catheter Ablation*
Pericardium / physiology*
Grant Support
48266//PHS HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Canine ventricular myocyte beta2-adrenoceptors are not functionally coupled to L-type calcium curren...
Next Document:  Characterization of a novel missense mutation in the pore of HERG in a patient with long QT syndrome...