Document Detail

Sequential change of asymmetric dimethylarginine levels after initiation of peritoneal dialysis in patients with end-stage renal disease.
MedLine Citation:
PMID:  20883285     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: We hypothesized that the asymmetric dimethylarginine (ADMA) metabolism in end-stage renal disease may be linked to the rate of protein turnover and to the vast pool of amino acids. In order to determine a correlation between the plasma levels of ADMA and the protein catabolic rate, we measured the ADMA levels as well as nutritional markers such as the normalized protein catabolic rate (nPCR) in patients with newly initiated continuous ambulatory peritoneal dialysis (CAPD).
METHODS: Twenty-four patients were recruited for this study. All patients were on the standard CAPD protocol, and followed for at least 1 year. Blood samples were collected at baseline before the initiation of peritoneal dialysis, and every 6 months for 1 year. The blood parameters studied included the serum albumin, total cholesterol, glucose, urea nitrogen, creatinine and ADMA. Peritoneal equilibrium test and measurements of weekly Kt/Vurea and nPCR were performed within 4 weeks of the blood sampling.
RESULTS: The change of ADMA levels over 1 year was positively correlated with that of haemoglobin (r = 0.592, P = 0.002) and nPCR during the same period (r = 0.508, P = 0.026).
CONCLUSION: The findings of our study suggest that nPCR might influence the change of ADMA levels after initiation of CAPD.
Kwan-Hyun Lee; Hyo-Wook Gil; Jong-Oh Yang; Eun-Young Lee; Sae-Yong Hong
Related Documents :
20139065 - Impact of peritoneal transport characteristics on cardiac function in paediatric perito...
19910565 - Peritoneal small solute clearance is nonlinearly related to patient survival in the aus...
8534695 - Infection rates in end-stage renal disease patients treated with ccpd and capd using th...
2096925 - Factors predisposing and contributing to peritonitis during chronic peritoneal dialysis...
1324425 - Distal small fiber neuropathy: results of tests of sweating and autonomic cardiovascula...
22384765 - Transcranial doppler monitoring of middle cerebral artery during verbal stimulation in ...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nephrology (Carlton, Vic.)     Volume:  15     ISSN:  1440-1797     ISO Abbreviation:  Nephrology (Carlton)     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-10-04     Completed Date:  2011-02-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9615568     Medline TA:  Nephrology (Carlton)     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  639-43     Citation Subset:  IM    
Copyright Information:
© 2010 The Authors. Nephrology © 2010 Asian Pacific Society of Nephrology.
Department of Internal Medicine, Soonchunhyang University Hospital, Cheonan City, Korea.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Arginine / analogs & derivatives*,  blood
Biological Markers / blood
Kidney Failure, Chronic / blood,  therapy*
Middle Aged
Nutritional Status
Peritoneal Dialysis, Continuous Ambulatory*
Time Factors
Treatment Outcome
Reg. No./Substance:
0/Biological Markers; 30315-93-6/N,N-dimethylarginine; 74-79-3/Arginine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Stringent glycaemic control prolongs survival in diabetic patients with end-stage renal disease on h...
Next Document:  Association of polymorphisms within the transforming growth factor-?1 gene with diabetic nephropathy...