| Sequential analysis of testicular lesions and serum hormone levels in rats treated with a Psoralea corylifolia extract. | |
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MedLine Citation:
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PMID: 14630124 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In order to clarify pathogenetic targets for the testicular toxicity of a extract of Psoralea corylifolia (P. corylifolia), F344 rats were fed diet containing 3% P. corylifolia extract for up to 12 weeks and subjected to hormone assays and histopathological examination on the testis and epididymis at weeks 1, 2, 4, 8 and 12 (Exp 1). Similar analyses were performed on 1, 3, 7 and 14 days after a single gavage administration of the P. corylifolia extract at a dose of 10 g/kg b.w. (Exp 2). In Exp 1, increase in the numbers of degenerated and exfoliated germ cells and loss of elongated spermatids beyond steps 7 or 8 were initially observed in the seminiferous tubules at week 1, followed by more pronounced degeneration of germ cells with depletion of post-meiotic populations from week 2. The tubular degeneration was associated with Leydig cell atrophy and persistent reduction of serum testosterone and FSH levels throughout the treatment period and a slight reduction of serum LH in later stages. In Exp 2, reduction of serum testosterone and FSH levels preceded degeneration of germ cells in stage VII and VIII tubules at 3 and 7 days after the administration. The results suggest that rapid androgen deprivation reflecting direct interference with Leydig cell function and simultaneous disturbance of the pituitary-testicular axis play pivotal roles in P. corylifolia extract-induced germ cell injury in seminiferous tubules. |
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Authors:
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T Takizawa; K Mitsumori; H Takagi; M Nasu; K Yasuhara; H Onodera; T Imai; M Hirose |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association Volume: 42 ISSN: 0278-6915 ISO Abbreviation: Food Chem. Toxicol. Publication Date: 2004 Jan |
Date Detail:
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Created Date: 2003-11-21 Completed Date: 2004-02-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8207483 Medline TA: Food Chem Toxicol Country: England |
Other Details:
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Languages: eng Pagination: 1-7 Citation Subset: IM |
Affiliation:
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Division of Pathology, National Institute of Health Sciences, 1-18-1, Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Weight / drug effects Epididymis / drug effects Follicle Stimulating Hormone / blood Germ Cells / drug effects Hormones / blood* Luteinizing Hormone / blood Male Organ Size / drug effects Plant Extracts / toxicity Psoralea / toxicity* Rats Rats, Inbred F344 Seminiferous Tubules / pathology Testicular Diseases / chemically induced*, pathology Testis / drug effects, pathology* Testosterone / blood |
| Chemical | |
Reg. No./Substance:
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0/Hormones; 0/Plant Extracts; 58-22-0/Testosterone; 9002-67-9/Luteinizing Hormone; 9002-68-0/Follicle Stimulating Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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