Document Detail

Sequential analysis of hepatic carcinogenesis. Regeneration of liver after carbon tetrachloride-induced liver necrosis when hepatocyte proliferation is inhibited by 2-acetylaminofluorene.
MedLine Citation:
PMID:  6823098     Owner:  NLM     Status:  MEDLINE    
The effect of inhibition of hepatocyte proliferation by dietary 2-acetylaminofluorene (2-AAF) on the restoration of liver in rats after a necrogenic dose of carbon tetrachloride has been studied. The liver weights remained low during the entire feeding period of the 2-AAF, and virtually no hepatocyte proliferation was seen, as determined autoradiographically after thymidine incorporation and by the absence of mitotic figures. Oval cell proliferation was extensive. Morphometric analysis showed (a) equal and maximum liver cell necrosis by 24 hours in both the experimental and control groups, (b) similar kinetics of removal of dead liver cells, and (c) similar values for the mean liver cell area. The distance between the portal triad and terminal hepatic vein in animals on the dietary 2-AAF was considerably reduced. Massive hepatocyte proliferation began after termination of the 2-AAF diet, and the liver returned to normal appearance within 14 days. The oval cells disappeared during this period of liver cell restoration. A new hypothesis for oval cell proliferation based on differential inhibition of hepatocyte proliferation resulting in unbalanced growth of ductular cells is presented.
A K Ghoshal; B Mullen; A Medline; E Farber
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Laboratory investigation; a journal of technical methods and pathology     Volume:  48     ISSN:  0023-6837     ISO Abbreviation:  Lab. Invest.     Publication Date:  1983 Feb 
Date Detail:
Created Date:  1983-03-24     Completed Date:  1983-03-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376617     Medline TA:  Lab Invest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  224-30     Citation Subset:  IM    
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MeSH Terms
2-Acetylaminofluorene / pharmacology*
Carbon Tetrachloride / adverse effects
Cell Division / drug effects
Liver / cytology,  pathology*
Liver Neoplasms / chemically induced,  pathology*
Liver Regeneration / drug effects*
Rats, Inbred F344
Grant Support
Reg. No./Substance:
53-96-3/2-Acetylaminofluorene; 56-23-5/Carbon Tetrachloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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