| Sequential danazol/leuprolide acetate therapy for ovarian suppression in an in vitro fertilization patient unresponsive to leuprolide acetate. | |
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MedLine Citation:
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PMID: 9086335 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report a case of pituitary-ovarian suppression obtained with sequential danazol/leuprolide acetate administration in a patient undergoing in vitro fertilization and unresponsive to leuprolide acetate alone and sequential oral contraceptive-leuprolide acetate therapy. Leuprolide acetate (1 mg daily subcutaneously) was administered after 5 weeks of danazol treatment (800 mg daily) while the latter was maintained for 1 additional week. Ovarian activity was assessed by transvaginal ultrasonography and serum estradiol determination. After 5 weeks of danazol therapy, ovarian arrest was obtained despite the fact that gonadotropin serum levels did not change relative to basal values. Leuprolide acetate injection for 14 days was associated with a decrease in serum concentrations of follicle-stimulating hormone and luteinizing hormone and a further decrease of the estradiol level. We conclude that sequential danazol/leuprolide acetate therapy is a useful alternative for obtaining ovarian arrest in patients unresponsive to leuprolide acetate alone. |
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Authors:
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J Balasch; F Fábregues; M Creus; J A Vanrell |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology Volume: 11 ISSN: 0951-3590 ISO Abbreviation: Gynecol. Endocrinol. Publication Date: 1997 Feb |
Date Detail:
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Created Date: 1997-05-29 Completed Date: 1997-05-29 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8807913 Medline TA: Gynecol Endocrinol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 21-4 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Faculty of Medicine, University of Barcelona, Hospital Clínic i Provincial, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Contraceptives, Oral / administration & dosage Danazol / administration & dosage*, therapeutic use Embryo Transfer Estradiol / blood Estrogen Antagonists / administration & dosage*, therapeutic use Ethinyl Estradiol / administration & dosage Female Fertilization in Vitro* Follicle Stimulating Hormone / blood Humans Leuprolide / administration & dosage*, therapeutic use Levonorgestrel / administration & dosage Luteinizing Hormone / blood Ovulation Induction Ultrasonography |
| Chemical | |
Reg. No./Substance:
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0/Contraceptives, Oral; 0/Estrogen Antagonists; 17230-88-5/Danazol; 50-28-2/Estradiol; 53714-56-0/Leuprolide; 57-63-6/Ethinyl Estradiol; 797-63-7/Levonorgestrel; 9002-67-9/Luteinizing Hormone; 9002-68-0/Follicle Stimulating Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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