| Sequential MRI changes in Wilson's disease with de-coppering therapy: a study of 50 patients. | |
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MedLine Citation:
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PMID: 17709362 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Wilson's disease (WD) is clinically and radiologically a dynamic disorder. However, there is a paucity of studies involving sequential MRI changes in this disease with or without therapy This study looked at serial MRI changes and their clinical correlate in patients with WD The severity of MRI changes using 1.5 T MRI in 50 patients with WD was graded based on alteration in signal intensity of focal lesions and atrophy. Details of clinical manifestations, Schwab and England Activities of daily living (MSEADL) score, Neurological Symptom Score (NSS) and Chu staging were recorded. Clinical severity and disability scores were correlated with MRI scores using SPSS v10 The mean age at onset of illness and diagnosis was 12.8+/-5.6 years and 14.4+/-6.0 years, respectively. At the time of first MRI, patients had been treated for 49.0+/-77.3 months. At a follow-up of 24.2+/-12.2 months, clinically 36 patients had improved, 9 remained the same and 5 had worsened. Serial imaging revealed an improvement in MRI parameters in 35 patients, no significant changes in 10, worsening in 4 and an admixture of resolving and evolving changes in 1. The overall MRI score improved from 8.2+/-5.7 to 5.9+/-6.6. There was an improvement in measures of disability and impairment in all: Chu stage, 11.5+/-0.7 to 1.3+/-0.6; MSEADL score (%), 79.7+/-27.6 to 88.0+/-25.4; NSS, 10.6+/-11.2 to 8.0+/-11.6, with good clinico-radiological correlation. Patients with extensive changes, white-matter involvement and severe diffuse atrophy had a poor prognosis In conclusion, the majority of patients with WD showed variable improvement in clinical and MRI features when treated. |
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Authors:
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S Sinha; A B Taly; L K Prashanth; S Ravishankar; G R Arunodaya; M K Vasudev |
Publication Detail:
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Type: Journal Article Date: 2007-08-20 |
Journal Detail:
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Title: The British journal of radiology Volume: 80 ISSN: 1748-880X ISO Abbreviation: Br J Radiol Publication Date: 2007 Sep |
Date Detail:
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Created Date: 2007-10-11 Completed Date: 2007-10-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0373125 Medline TA: Br J Radiol Country: England |
Other Details:
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Languages: eng Pagination: 744-9 Citation Subset: AIM; IM |
Affiliation:
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Department of Neurology, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India. sanjib_sinha@nimhans.kar.nic.in |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Astringents / therapeutic use Chelating Agents / therapeutic use* Child Disease Progression Female Health Status Indicators Hepatolenticular Degeneration / diagnosis* Humans India Magnetic Resonance Imaging Male Penicillamine / therapeutic use Prognosis Prospective Studies Zinc Sulfate / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Astringents; 0/Chelating Agents; 52-67-5/Penicillamine; 7733-02-0/Zinc Sulfate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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