Document Detail


Sequential MRI changes in Wilson's disease with de-coppering therapy: a study of 50 patients.
MedLine Citation:
PMID:  17709362     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Wilson's disease (WD) is clinically and radiologically a dynamic disorder. However, there is a paucity of studies involving sequential MRI changes in this disease with or without therapy This study looked at serial MRI changes and their clinical correlate in patients with WD The severity of MRI changes using 1.5 T MRI in 50 patients with WD was graded based on alteration in signal intensity of focal lesions and atrophy. Details of clinical manifestations, Schwab and England Activities of daily living (MSEADL) score, Neurological Symptom Score (NSS) and Chu staging were recorded. Clinical severity and disability scores were correlated with MRI scores using SPSS v10 The mean age at onset of illness and diagnosis was 12.8+/-5.6 years and 14.4+/-6.0 years, respectively. At the time of first MRI, patients had been treated for 49.0+/-77.3 months. At a follow-up of 24.2+/-12.2 months, clinically 36 patients had improved, 9 remained the same and 5 had worsened. Serial imaging revealed an improvement in MRI parameters in 35 patients, no significant changes in 10, worsening in 4 and an admixture of resolving and evolving changes in 1. The overall MRI score improved from 8.2+/-5.7 to 5.9+/-6.6. There was an improvement in measures of disability and impairment in all: Chu stage, 11.5+/-0.7 to 1.3+/-0.6; MSEADL score (%), 79.7+/-27.6 to 88.0+/-25.4; NSS, 10.6+/-11.2 to 8.0+/-11.6, with good clinico-radiological correlation. Patients with extensive changes, white-matter involvement and severe diffuse atrophy had a poor prognosis In conclusion, the majority of patients with WD showed variable improvement in clinical and MRI features when treated.
Authors:
S Sinha; A B Taly; L K Prashanth; S Ravishankar; G R Arunodaya; M K Vasudev
Publication Detail:
Type:  Journal Article     Date:  2007-08-20
Journal Detail:
Title:  The British journal of radiology     Volume:  80     ISSN:  1748-880X     ISO Abbreviation:  Br J Radiol     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-10-11     Completed Date:  2007-10-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0373125     Medline TA:  Br J Radiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  744-9     Citation Subset:  AIM; IM    
Affiliation:
Department of Neurology, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India. sanjib_sinha@nimhans.kar.nic.in
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Astringents / therapeutic use
Chelating Agents / therapeutic use*
Child
Disease Progression
Female
Health Status Indicators
Hepatolenticular Degeneration / diagnosis*
Humans
India
Magnetic Resonance Imaging
Male
Penicillamine / therapeutic use
Prognosis
Prospective Studies
Zinc Sulfate / therapeutic use
Chemical
Reg. No./Substance:
0/Astringents; 0/Chelating Agents; 52-67-5/Penicillamine; 7733-02-0/Zinc Sulfate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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