| Sequential FDG-PET/CT after Neoadjuvant Chemotherapy is a Predictor of Histopathologic Response in Patients with Head and Neck Squamous Cell Carcinoma. | |
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MedLine Citation:
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PMID: 20552285 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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PURPOSE: To evaluate whether 2-deoxy-2-[(18)F]fluoro-D-glucose positron emission tomography/computed tomography (FDG-PET/CT) more accurately predicts the histopathologic response to neoadjuvant chemotherapy (NAC) than magnetic resonance imaging (MRI) in patients with head and neck squamous cell carcinoma (HNSCC). PROCEDURES: Sixteen patients with HNSCC underwent FDG-PET/CT and MRI scans before and after one cycle of NAC, followed by surgical resection. The 26 surgically resected specimens of the 16 patients were analyzed. Decreases in maximum standardized uptake value (SUV(max)) or in tumor maximum size (diameter(max)) were calculated, and their accuracies for the prediction of histopathologic response were evaluated. RESULTS: In histopathologic responders (n = 7), percent decreases in SUV(max) were significantly higher (P < 0.001) than in non-responders (n = 19). Applying a cut-off point of 55.5%, the histopathologic response could be predicted with a sensitivity and specificity of 86% and 95%, respectively. CONCLUSION: FDG-PET/CT can predict histopathologic NAC responses with higher accuracy than MRI in HNSCC patients. |
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Authors:
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Masahiro Kikuchi; Shogo Shinohara; Yuji Nakamoto; Yu Usami; Keizo Fujiwara; Tsunemichi Adachi; Shin-Ya Hori; Yosuke Tona; Hiroshi Yamazaki; Yukihiro Imai; Yasushi Naito |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging Volume: 13 ISSN: 1860-2002 ISO Abbreviation: Mol Imaging Biol Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-09 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101125610 Medline TA: Mol Imaging Biol Country: United States |
Other Details:
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Languages: eng Pagination: 368-77 Citation Subset: IM |
Affiliation:
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Department of Otolaryngology, Kobe City Medical Center General Hospital, 4-6 Minatojima-Nakamachi, Chuo-ku, Kobe, 650-0046, Japan, masahirok@kcgh.gr.jp. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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